Functional Connectivity As a Means to Delineate Differences Between Treatment-resistant and Treatment-responsive Schizophrenia

Overview

Journal J Neurophysiol

Publisher American Physiological Society

Specialties Neurology
Physiology

Date 2016 Jan 15

PMID 26763784

Citations 5

Authors

Sara Paul

Nathan Sharfman

Affiliations

Soon will be listed here.

Abstract

It has been estimated that one-third of schizophrenia patients are treatment resistant (TRS). Recent studies have shown that functional connectivity (FC) can be used for measuring connections between brain regions in diseased states. White, Wigton, Joyce, Collier, Fornito, and Shergill (Neuropsychopharmacology First published September 9, 2015; doi:10.1038/npp.2015.277) used FC to identify differences between schizophrenia patients responding to antipsychotic treatment and TRS patients. Their results support the idea that the groups differ not only in treatment response but also neurophysiologically through differences in FC.

Citing Articles

Aberrant connectivity in the hippocampus, bilateral insula and temporal poles precedes treatment resistance in first-episode psychosis: a prospective resting-state functional magnetic resonance imaging study with connectivity concordance mapping.

Skouras S, Kleinert M, Lee E, Hui C, Suen Y, Camchong J Brain Commun. 2024; 6(3):fcae094.

PMID: 38707706 PMC: 11069118. DOI: 10.1093/braincomms/fcae094.

Treatment-resistant schizophrenia: How far have we traveled?.

Pandey A, Kalita K Front Psychiatry. 2022; 13:994425.

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Abnormal Fractional Amplitude of Low-Frequency Fluctuation as a Potential Imaging Biomarker for First-Episode Major Depressive Disorder: A Resting-State fMRI Study and Support Vector Machine Analysis.

Gao Y, Wang X, Xiong Z, Ren H, Liu R, Wei Y Front Neurol. 2021; 12:751400.

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Treatment-Resistant Schizophrenia: Genetic and Neuroimaging Correlates.

Vita A, Minelli A, Barlati S, Deste G, Giacopuzzi E, Valsecchi P Front Pharmacol. 2019; 10:402.

PMID: 31040787 PMC: 6476957. DOI: 10.3389/fphar.2019.00402.

Neural substrate of unrelenting negative symptoms in schizophrenia: a longitudinal resting-state fMRI study.

Li M, Deng W, Das T, Li Y, Zhao L, Ma X Eur Arch Psychiatry Clin Neurosci. 2017; 268(7):641-651.

PMID: 29128871 DOI: 10.1007/s00406-017-0851-5.

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