Functionalized Mesoporous Bioactive Glass Scaffolds for Enhanced Bone Tissue Regeneration

Overview

Journal Sci Rep

Specialty Science

Date 2016 Jan 15

PMID 26763311

Citations 30

Authors

Xingdi Zhang

Deliang Zeng

Nan Li

Jin Wen

Xinquan Jiang

Changsheng Liu

Yongsheng Li

Affiliations

Soon will be listed here.

Abstract

Mesoporous bioactive glass (MBG), which possesses excellent bioactivity, biocompatibility and osteoconductivity, has played an important role in bone tissue regeneration. However, it is difficult to prepare MBG scaffolds with high compressive strength for applications in bone regeneration; this difficulty has greatly hindered its development and use. To solve this problem, a simple powder processing technique has been successfully developed to fabricate a novel type of MBG scaffold (MBGS). Furthermore, amino or carboxylic groups could be successfully grafted onto MBGSs (denoted as N-MBGS and C-MBGS, respectively) through a post-grafting process. It was revealed that both MBGS and the functionalized MBGSs could significantly promote the proliferation and osteogenic differentiation of bMSCs. Due to its positively charged surface, N-MBGS presented the highest in vitro osteogenic capability of the three samples. Moreover, in vivo testing results demonstrated that N-MBGS could promote higher levels of bone regeneration compared with MBGS and C-MBGS. In addition to its surface characteristics, it is believed that the decreased degradation rate of N-MBGS plays a vital role in promoting bone regeneration. These findings indicate that MBGSs are promising materials with potential practical applications in bone regeneration, which can be successfully fabricated by combining a powder processing technique and post-grafting process.

Citing Articles

Synergistic Effect of Strontium Doping and Surfactant Addition in Mesoporous Bioactive Glass for Enhanced Osteogenic Bioactivity and Advanced Bone Regeneration.

Chen Y, Ma T, Chang P, Chiou Y, Chang W, Weng C Polymers (Basel). 2025; 17(2).

PMID: 39861259 PMC: 11768331. DOI: 10.3390/polym17020187.

Fabrication and characterizations of simvastatin-containing mesoporous bioactive glass and molybdenum disulfide scaffold for bone tissue engineering.

Murugan S, Appana Dalavi P, Surya S, Anil S, Gupta S, Shetty R APL Bioeng. 2023; 7(4):046115.

PMID: 38058994 PMC: 10697724. DOI: 10.1063/5.0172002.

[Research progress on biocomposites based on bioactive glass].

Peng Y, Lan L, Mu J, Hou S, Cheng L Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2023; 40(4):805-811.

PMID: 37666773 PMC: 10477385. DOI: 10.7507/1001-5515.202202016.

Revolutionizing bone regeneration: advanced biomaterials for healing compromised bone defects.

Awad K, Ahuja N, Yacoub A, Brotto L, Young S, Mikos A Front Aging. 2023; 4:1217054.

PMID: 37520216 PMC: 10376722. DOI: 10.3389/fragi.2023.1217054.

Prosthetic Joint Infections: Biofilm Formation, Management, and the Potential of Mesoporous Bioactive Glass as a New Treatment Option.

Almasri D, Dahman Y Pharmaceutics. 2023; 15(5).

PMID: 37242643 PMC: 10222612. DOI: 10.3390/pharmaceutics15051401.

References

Zeng D, Xia L, Zhang W, Huang H, Wei B, Huang Q . Maxillary sinus floor elevation using a tissue-engineered bone with calcium-magnesium phosphate cement and bone marrow stromal cells in rabbits. Tissue Eng Part A. 2011; 18(7-8):870-81. DOI: 10.1089/ten.TEA.2011.0379. View

Yan X, Huang X, Yu C, Deng H, Wang Y, Zhang Z . The in-vitro bioactivity of mesoporous bioactive glasses. Biomaterials. 2006; 27(18):3396-403. DOI: 10.1016/j.biomaterials.2006.01.043. View

Wu C, Zhou Y, Xu M, Han P, Chen L, Chang J . Copper-containing mesoporous bioactive glass scaffolds with multifunctional properties of angiogenesis capacity, osteostimulation and antibacterial activity. Biomaterials. 2012; 34(2):422-33. DOI: 10.1016/j.biomaterials.2012.09.066. View

Zhang J, Zhou H, Yang K, Yuan Y, Liu C . RhBMP-2-loaded calcium silicate/calcium phosphate cement scaffold with hierarchically porous structure for enhanced bone tissue regeneration. Biomaterials. 2013; 34(37):9381-92. DOI: 10.1016/j.biomaterials.2013.08.059. View

Xynos I, Edgar A, Buttery L, Hench L, Polak J . Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis. Biochem Biophys Res Commun. 2000; 276(2):461-5. DOI: 10.1006/bbrc.2000.3503. View

Hutmacher D . Scaffolds in tissue engineering bone and cartilage. Biomaterials. 2000; 21(24):2529-43. DOI: 10.1016/s0142-9612(00)00121-6. View

Kasemo B, Gold J . Implant surfaces and interface processes. Adv Dent Res. 2001; 13:8-20. DOI: 10.1177/08959374990130011901. View

Keselowsky B, Collard D, Garcia A . Surface chemistry modulates fibronectin conformation and directs integrin binding and specificity to control cell adhesion. J Biomed Mater Res A. 2003; 66(2):247-59. DOI: 10.1002/jbm.a.10537. View

Jones J, Hench L . Factors affecting the structure and properties of bioactive foam scaffolds for tissue engineering. J Biomed Mater Res B Appl Biomater. 2003; 68(1):36-44. DOI: 10.1002/jbm.b.10071. View

10.

Kokubo T, Kushitani H, Sakka S, Kitsugi T, Yamamuro T . Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W. J Biomed Mater Res. 1990; 24(6):721-34. DOI: 10.1002/jbm.820240607. View

11.

Lee J, Lee J, Khang G, Lee H . Interaction of cells on chargeable functional group gradient surfaces. Biomaterials. 1997; 18(4):351-8. DOI: 10.1016/s0142-9612(96)00128-7. View

12.

Yan X, Yu C, Zhou X, Tang J, Zhao D . Highly ordered mesoporous bioactive glasses with superior in vitro bone-forming bioactivities. Angew Chem Int Ed Engl. 2004; 43(44):5980-4. DOI: 10.1002/anie.200460598. View

13.

Curran J, Chen R, Hunt J . Controlling the phenotype and function of mesenchymal stem cells in vitro by adhesion to silane-modified clean glass surfaces. Biomaterials. 2005; 26(34):7057-67. DOI: 10.1016/j.biomaterials.2005.05.008. View

14.

Curran J, Chen R, Hunt J . The guidance of human mesenchymal stem cell differentiation in vitro by controlled modifications to the cell substrate. Biomaterials. 2006; 27(27):4783-93. DOI: 10.1016/j.biomaterials.2006.05.001. View

15.

Xia W, Chang J . Well-ordered mesoporous bioactive glasses (MBG): a promising bioactive drug delivery system. J Control Release. 2005; 110(3):522-30. DOI: 10.1016/j.jconrel.2005.11.002. View

16.

Balas F, Manzano M, Horcajada P, Vallet-Regi M . Confinement and controlled release of bisphosphonates on ordered mesoporous silica-based materials. J Am Chem Soc. 2006; 128(25):8116-7. DOI: 10.1021/ja062286z. View

17.

Arima Y, Iwata H . Effect of wettability and surface functional groups on protein adsorption and cell adhesion using well-defined mixed self-assembled monolayers. Biomaterials. 2007; 28(20):3074-82. DOI: 10.1016/j.biomaterials.2007.03.013. View

18.

Tzoneva R, Faucheux N, Groth T . Wettability of substrata controls cell-substrate and cell-cell adhesions. Biochim Biophys Acta. 2007; 1770(11):1538-47. DOI: 10.1016/j.bbagen.2007.07.008. View

19.

Zhang F, Chang J, Lin K, Lu J . Preparation, mechanical properties and in vitro degradability of wollastonite/tricalcium phosphate macroporous scaffolds from nanocomposite powders. J Mater Sci Mater Med. 2007; 19(1):167-73. DOI: 10.1007/s10856-006-0056-3. View

20.

Wu C, Ramaswamy Y, Zhu Y, Zheng R, Appleyard R, Howard A . The effect of mesoporous bioactive glass on the physiochemical, biological and drug-release properties of poly(DL-lactide-co-glycolide) films. Biomaterials. 2009; 30(12):2199-208. DOI: 10.1016/j.biomaterials.2009.01.029. View