Neutrophils Influx and Proinflammatory Cytokines Inhibition by Sodium Salicylate, Unlike Aspirin, in Candida Albicans-induced Peritonitis Model

Overview

Journal Folia Microbiol (Praha)

Publisher Springer

Specialty Microbiology

Date 2016 Jan 15

PMID 26762336

Citations 2

Authors

Priscilla Aparecida Tartari Pereira

Daniel Bini

Fernanda Bovo

Lucia Helena Faccioli

Marta Chagas Monteiro

Affiliations

Soon will be listed here.

Abstract

Sodium salicylate (NaS) and aspirin (ASA) are known to have a variety of effects on microorganisms, such as fungus (C. albicans and C. neoformans), moreover, it have effects in leukocyte adhesion and migration in vitro. In this report, we investigated the effect of ASA and NaS in neutrophil migration and cytokine production in C. albicans-induced peritonitis murine model. For this, mice were treated intraperitoneally (i.p) or orally (po) with NaS or ASA; after they were stimulated i.p. with C. albicans, the cellular migration was evaluated 24 h after stimulation. NaS, in mice treated i.p., unlike ASA, was able to inhibit the neutrophil migration and proinflammatory cytokine production induced by C. albicans, such as TNF-α, IL-1, IFN-γ, IL-12, and IL-10, but did not alter the IL-4 levels in these animals. However, the po treatment with same the dose of NaS or ASA did not affect the influx of this cell for inflammatory site. These results suggest that the NaS inhibits cellular migration and proinflammatory cytokine by different anti-inflammatory mechanism compared to ASA.

Citing Articles

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