Astrocyte-Microglia Cross Talk Through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

Overview

Journal J Neurosci

Specialty Neurology

Date 2016 Jan 14

PMID 26758846

Citations 297

Authors

Hong Lian

Alexandra Litvinchuk

Angie C-A Chiang

Nadia Aithmitti

Joanna L Jankowsky

Hui Zheng

Affiliations

Soon will be listed here.

Abstract

Significance Statement: The complement pathway is activated in Alzheimer's disease. Here we show that the central complement factor C3 secreted from astrocytes interacts with microglial C3a receptor (C3aR) to mediate β-amyloid pathology and neuroinflammation in AD mouse models. Our study provides support for targeting C3aR as a potential therapy for Alzheimer's disease.

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