Radiation-induced Eosinophilic, Polymorphic, and Pruritic Eruption in a Pig Skin Model

Overview

Journal Lab Anim Res

Date 2016 Jan 13

PMID 26755924

Citations 4

Authors

Joong Sun Kim

Won Seok Jang

Min Ji Bae

Sunhoo Park

Seung Sook Lee

Affiliations

Soon will be listed here.

Abstract

Eosinophilic, polymorphic and pruritic eruption associated with radiotherapy (EPPER) can occur in cancer patients after irradiation. In this study, we characterized the clinical and histopathological features of pig skin that developed widespread polymorphic and pruritic skin lesions following localized 50 Gy gamma-irradiation. The pigs developed pruritus 5-7 weeks after irradiation, and infiltration of the dermis by eosinophils was detected 4-7 weeks after irradiation. The irradiated animals also showed transiently increased numbers of peripheral eosinophils 5-7 weeks after treatment. Irradiation induced desquamation after 2-4 weeks, which and the desquamation gradually resolved after 7 weeks. These pathological changes correspond to those seen in irradiated human skin, indicating that this model could be useful for elucidating the pathogenesis of EPPER and for developing therapeutic and prophylactic methods.

Citing Articles

Eosinophilic, polymorphic, and pruritic eruption associated with radiation therapy in two patients diagnosed with prostate cancer.

Barbu M, Anghel R, Ricu G, Tebeica T, Patru R, Michire A Clin Case Rep. 2023; 11(5):e7266.

PMID: 37180326 PMC: 10172447. DOI: 10.1002/ccr3.7266.

Effect of Enrichment Items on the Physiology and Behavior of Sows in the Third Trimester of Pregnancy.

Li S, Hu H, Huang J, Yang Y, Xu W, Chen J Animals (Basel). 2022; 12(11).

PMID: 35681820 PMC: 9179893. DOI: 10.3390/ani12111355.

Abnormalities of hair structure and skin histology derived from CRISPR/Cas9-based knockout of phospholipase C-delta 1 in mice.

Liu Y, Liu W, Jia J, Chen B, Chen H, Liu Y J Transl Med. 2018; 16(1):141.

PMID: 29793503 PMC: 5968471. DOI: 10.1186/s12967-018-1512-9.

Generation of DKK1 transgenic Tibet minipigs by somatic cell nuclear transfer (SCNT).

Liu W, Wu L, Yue M, Nashun B, Tang H, Chen Y Oncotarget. 2017; 8(43):74331-74339.

PMID: 29088789 PMC: 5650344. DOI: 10.18632/oncotarget.20604.

References

Lam Cham Kee H, Charra-Brunaud C, Cuny J, Reigneau M, G Vogin , Peiffert D . [Case report of EPPER Syndrome (eosinophilic polymorphic pruritic eruption associated with radiotherapy) in a patient treated against endometrial cancer]. Cancer Radiother. 2013; 17(1):54-7. DOI: 10.1016/j.canrad.2012.10.012. View

Spry C, Davies J, Tai P, Olsen E, Oakley C, Goodwin J . Clinical features of fifteen patients with the hypereosinophilic syndrome. Q J Med. 1983; 52(205):1-22. View

Shimamoto N, Shirase T, Yoshikawa Y . Vesicular form of eosinophilic, polymorphic, and pruritic eruption associated with radiotherapy confined to the irradiated area. J Dermatol. 2013; 40(3):228-9. DOI: 10.1111/1346-8138.12053. View

Sullivan T, Eaglstein W, Davis S, Mertz P . The pig as a model for human wound healing. Wound Repair Regen. 2001; 9(2):66-76. DOI: 10.1046/j.1524-475x.2001.00066.x. View

Garcia-Donoso C, Tardio J, Arias D, Romero A, Borbujo J . Eosinophilic, polymorphic and pruritic eruption associated with radiotherapy (EPPER) in two patients with breast tumour. J Eur Acad Dermatol Venereol. 2007; 21(8):1102-4. DOI: 10.1111/j.1468-3083.2007.02180.x. View

DEDICK Jr A, WHELAN V . Generalized skin reaction following deep x-ray therapy. Radiology. 1959; 72(5):751-3. DOI: 10.1148/72.5.751. View

Davis J, PACK G . Erythema multiforme following deep x-ray therapy. AMA Arch Derm Syphilol. 1952; 66(1):41-8. DOI: 10.1001/archderm.1952.01530260044003. View

Kim J, Rhim K, Jang W, Lee S, Son Y, Lee S . β-irradiation (¹⁶⁶Ho patch)-induced skin injury in mini-pigs: effects on NF-κB and COX-2 expression in the skin. J Vet Sci. 2014; 16(1):1-9. PMC: 4367138. DOI: 10.4142/jvs.2015.16.1.1. View

van den Hoogenband H . Skin lesions as the first manifestation of the hypereosinophilic syndrome. Clin Exp Dermatol. 1982; 7(3):267-71. DOI: 10.1111/j.1365-2230.1982.tb02426.x. View

10.

Rueda R, Valencia I, Covelli C, Escobar C, Alzate A, Saldarriaga B . Eosinophilic, polymorphic, and pruritic eruption associated with radiotherapy. Arch Dermatol. 1999; 135(7):804-10. DOI: 10.1001/archderm.135.7.804. View

11.

Lee D, Kim Y . A pustular form of eosinophilic, polymorphic, and pruritic eruption associated with radiotherapy. J Am Acad Dermatol. 2011; 65(2):e51-e53. DOI: 10.1016/j.jaad.2010.12.026. View

12.

KUROHARA S, HEMPELMANN L, ENGLANDER C, Fuller L, Rubin P . EOSINOPHILIA AFTER EXPOSURE TO IONIZING RADIATION. Radiat Res. 1964; 23:357-68. View

13.

Duschet P, Schwarz T, Gschnait F . Bullous pemphigoid after radiation therapy. J Am Acad Dermatol. 1988; 18(2 Pt 2):441-4. DOI: 10.1016/s0190-9622(88)70066-3. View

14.

Hill P, Lau P, Rybnicek J . Development of an owner-assessed scale to measure the severity of pruritus in dogs. Vet Dermatol. 2007; 18(5):301-8. DOI: 10.1111/j.1365-3164.2007.00616.x. View