A Prospective, Longitudinal Study of Sleep Disturbance and Comorbidity in Opiate Dependence (the ANRS Methaville Study)

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 2016 Jan 13

PMID 26753792

Citations 10

Authors

Sandra Nordmann

Caroline Lions

Antoine Vilotitch

Laurent Michel

Marion Mora

Bruno Spire

Gwenaelle Maradan

Alain Morel

Perrine Roux

M Patrizia Carrieri

Affiliations

Soon will be listed here.

Abstract

Rationale/objectives: Sleep disturbance is frequent in opioid-dependent patients. To date, no data are available about the impact of methadone maintenance treatment on sleep disturbance. Using 1-year follow-up data from the Methaville trial, we investigated the impact of methadone initiation and other correlates on sleep disturbance in opioid-dependent patients.

Methods: Sleep disturbance severity was evaluated using two items from different scales (Center for Epidemiological Studies Depression Scale for depression and Opiate Treatment Index). We assessed the effect of methadone and other correlates on sleep disturbance severity during follow-up (months 0, 6, and 12) using a mixed multinomial logistic regression model.

Results: We included 173 patients who had 1-year follow-up data on sleep disturbance, corresponding to 445 visits. At enrolment, 60.5 % reported medium to severe sleep disturbance. This proportion remained stable during methadone treatment: 54.0 % at month 6 and 55.4 % at month 12. The final multivariate model indicated that younger patients (odds ratio (OR) [95 % CI] 0.95 [0.90-1.00]), patients with pain (OR [95 % CI] 2.45 [1.13-5.32]), patients with high or very high nicotine dependence (OR [95 % CI] 5.89 [2.41-14.39]), and patients at suicidal risk (2.50 [1.13-5.52]) had a higher risk of severe sleep disturbance. Because of collinearity between suicidal risk and attention deficit hyperactivity disorder (ADHD) symptoms, ADHD was not associated with sleep disturbance in the final model. Receiving methadone treatment had no significant effect on sleep disturbance.

Conclusions: Sleep disturbance is frequent among opioid-dependent patients. It can be regarded as an important signal of more complex psychiatric comorbidities such as suicidal risk and ADHD. However, sleep disturbance should not be considered an obstacle to methadone maintenance treatment (MMT) initiation or continuation.

Citing Articles

Associations Among Sleep, Pain, and Medications for Opioid Use Disorder: a Scoping Review.

Hsaio C, DiMeola K, Jegede O, Funaro M, Langstengel J, Yaggi H Curr Addict Rep. 2025; 11(6):965-981.

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Spontaneous oxycodone withdrawal disrupts sleep, diurnal, and electrophysiological dynamics in rats.

Gulledge M, Carlezon Jr W, McHugh R, Kinard E, Prerau M, Chartoff E PLoS One. 2025; 20(1):e0312794.

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Feasibility and acceptability of wearing a neuromodulation device at night in individuals in recovery from opioid use disorder.

Meads K, Huettner S, Amata D, Johnson H, Devine J, Warnakulasuriya S Front Psychiatry. 2024; 15:1481795.

PMID: 39676914 PMC: 11640868. DOI: 10.3389/fpsyt.2024.1481795.

Sleep Deficiency and Opioid Use Disorder: Trajectory, Mechanisms, and Interventions.

Langstengel J, Yaggi H Clin Chest Med. 2022; 43(2):e1-e14.

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Wireless electroencephalography (EEG) to monitor sleep among patients being withdrawn from opioids: Evidence of feasibility and utility.

Dunn K, Finan P, Huhn A, Gamaldo C, Bergeria C, Strain E Exp Clin Psychopharmacol. 2021; 30(6):1016-1023.

PMID: 34096756 PMC: 8648854. DOI: 10.1037/pha0000483.

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