Association Between CRP and TNF-α Genes Variants and Cardiovascular Heart Disease in a Mexican Population: Protocol for a Case-Control Study

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2016 Jan 12

PMID 26751459

Citations 4

Authors

Yazmin Hernandez-Diaz

Carlos Alfonso Tovilla-Zarate

Isela Juarez-Rojop

Maria Lilia Lopez-Narvaez

Jose Francisco Alvarez-Camara

Thelma Beatriz Gonzalez-Castro

Affiliations

Soon will be listed here.

Abstract

Background: The C-reactive protein (CRP) and the tumor necrosis factor-alpha (TNF-α) are considered markers of inflammation and have been shown to predict the risk of incident cardiovascular events. However, few studies have undertaken a comprehensive examination of SNPs (single nucleotide polymorphisms) of the CRP and TNF-α genes; due to this, we will present a protocol study to evaluate the role of the CRP and TNF-α genes in Mexican individuals.

Methods/design: we will perform a case-control study to explore the CRP and TNF-α genotype distribution as well as the serum influence of rs1800947, rs1130864, rs2794521 and rs1205 (polymorphisms of the CRP gene) and rs361525, rs1800629, rs1799724, rs1800630, rs1799964 (of the TNF-α gene) in Mexican individuals who present coronary artery disease.

Ethics And Dissemination: a written informed consent will be obtained from all the participating subjects. An article detailing the results of the study will be submitted for publication in an international peer-reviewed journal, in accordance with STROBE criteria.

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