Introduction and Prolonged Circulation of G12 Rotaviruses in Sicily

Overview

Journal Epidemiol Infect

Publisher Cambridge University Press

Specialties Infectious Diseases
Public Health

Date 2016 Jan 9

PMID 26743189

Citations 5

Authors

G M Giammanco

F Bonura

F Di Bernardo

A Cascio

G Ferrera

P Dones

L Saporito

A Collura

D M Terranova

M Valenzise

M T Allu

N Casuccio

M Palermo

K Banyai

V Martella

S De Grazia

Affiliations

Soon will be listed here.

Abstract

Genotype G12 strains are now considered to be the sixth most prevalent human rotaviruses worldwide. In two Sicilian cities, Palermo and Messina, surveillance of rotavirus circulation performed since 1985 and 2009, respectively, did not detect G12 strains until 2012. From 2012 to 2014 rotavirus infection was detected in 29·7% of 1647 stool samples collected from children admitted for acute gastroenteritis to three Sicilian hospitals in Palermo, Messina and Ragusa. In 2012, G12P[8] was first detected in Palermo and then in Messina where it represented the second most frequent genotype (20% prevalence) after G1P[8]. Thereafter, G12 strains continued to circulate in Sicily, showing a marked prevalence in Ragusa (27·8%) in 2013 and in Palermo (21%) and Messina (16·6%) in 2014. All but one of the Sicilian G12 strains carried a P[8] VP4 genotype, whereas the single non-P[8] rotavirus strain was genotyped as G12P[9]. Phylogenetic analysis of the VP7 and VP4 sequences allowed distinction of several genetic lineages and separation of the G12P[8] strains into three cluster combinations. These findings indicate independent introductions of G12 rotavirus strains in Sicily in recent years.

Citing Articles

Impact of Vaccination on Rotavirus Genotype Diversity: A Nearly Two-Decade-Long Epidemiological Study before and after Rotavirus Vaccine Introduction in Sicily, Italy.

Bonura F, Mangiaracina L, Filizzolo C, Bonura C, Martella V, Ciarlet M Pathogens. 2022; 11(4).

PMID: 35456099 PMC: 9028787. DOI: 10.3390/pathogens11040424.

Molecular Epidemiology of Rotavirus Strains in Symptomatic and Asymptomatic Children in Manhiça District, Southern Mozambique 2008-2019.

Manjate F, Joao E, Chirinda P, Garrine M, Vubil D, Nobela N Viruses. 2022; 14(1).

PMID: 35062336 PMC: 8781303. DOI: 10.3390/v14010134.

Group A rotavirus surveillance before vaccine introduction in Italy, September 2014 to August 2017.

Ianiro G, Micolano R, Di Bartolo I, Scavia G, Monini M Euro Surveill. 2019; 24(15).

PMID: 30994104 PMC: 6470368. DOI: 10.2807/1560-7917.ES.2019.24.15.1800418.

Impact of rotavirus vaccination on rotavirus genotype distribution and diversity in England, September 2006 to August 2016.

Hungerford D, Allen D, Nawaz S, Collins S, Ladhani S, Vivancos R Euro Surveill. 2019; 24(6).

PMID: 30755297 PMC: 6373066. DOI: 10.2807/1560-7917.ES.2019.24.6.1700774.

Multiple Introductions and Antigenic Mismatch with Vaccines May Contribute to Increased Predominance of G12P[8] Rotaviruses in the United States.

Ogden K, Tan Y, Akopov A, Stewart L, McHenry R, Fonnesbeck C J Virol. 2018; 93(1).

PMID: 30333170 PMC: 6288334. DOI: 10.1128/JVI.01476-18.

References

Matthijnssens J, Heylen E, Zeller M, Rahman M, Lemey P, Van Ranst M . Phylodynamic analyses of rotavirus genotypes G9 and G12 underscore their potential for swift global spread. Mol Biol Evol. 2010; 27(10):2431-6. DOI: 10.1093/molbev/msq137. View

Samajdar S, Varghese V, Barman P, Ghosh S, Mitra U, Dutta P . Changing pattern of human group A rotaviruses: emergence of G12 as an important pathogen among children in eastern India. J Clin Virol. 2006; 36(3):183-8. DOI: 10.1016/j.jcv.2006.03.006. View

Das S, Varghese V, Chaudhury S, Barman P, Mahapatra S, Kojima K . Emergence of novel human group A rotavirus G12 strains in India. J Clin Microbiol. 2003; 41(6):2760-2. PMC: 156500. DOI: 10.1128/JCM.41.6.2760-2762.2003. View

Payne D, Boom J, Staat M, Edwards K, Szilagyi P, Klein E . Effectiveness of pentavalent and monovalent rotavirus vaccines in concurrent use among US children <5 years of age, 2009-2011. Clin Infect Dis. 2013; 57(1):13-20. PMC: 4618548. DOI: 10.1093/cid/cit164. View

Espejo P, Peralta F, Pacheres H, Del Valle L, Tapia A, Mayra J . Diarrhoea caused by rotavirus in a regional Peruvian hospital: determination of circulating genotypes. Trans R Soc Trop Med Hyg. 2014; 108(7):425-30. DOI: 10.1093/trstmh/tru059. View

Gouvea V, Santos N, Timenetsky M . Identification of bovine and porcine rotavirus G types by PCR. J Clin Microbiol. 1994; 32(5):1338-40. PMC: 263690. DOI: 10.1128/jcm.32.5.1338-1340.1994. View

Wangchuk S, Mitui M, Tshering K, Yahiro T, Bandhari P, Zangmo S . Dominance of emerging G9 and G12 genotypes and polymorphism of VP7 and VP4 of rotaviruses from Bhutanese children with severe diarrhea prior to the introduction of vaccine. PLoS One. 2014; 9(10):e110795. PMC: 4203849. DOI: 10.1371/journal.pone.0110795. View

Steyer A, Poljsak-Prijatelj M, Bufon T, Marcun-Varda N, Marin J . Rotavirus genotypes in Slovenia: unexpected detection of G8P[8] and G12P[8] genotypes. J Med Virol. 2007; 79(5):626-32. DOI: 10.1002/jmv.20811. View

Iturriza-Gomara M, Kang G, Gray J . Rotavirus genotyping: keeping up with an evolving population of human rotaviruses. J Clin Virol. 2004; 31(4):259-65. DOI: 10.1016/j.jcv.2004.04.009. View

10.

Iturriza-Gomara M, Dallman T, Banyai K, Bottiger B, Buesa J, Diedrich S . Rotavirus genotypes co-circulating in Europe between 2006 and 2009 as determined by EuroRotaNet, a pan-European collaborative strain surveillance network. Epidemiol Infect. 2010; 139(6):895-909. DOI: 10.1017/S0950268810001810. View

11.

Pietsch C, Liebert U . Human infection with G12 rotaviruses, Germany. Emerg Infect Dis. 2009; 15(9):1512-5. PMC: 2819891. DOI: 10.3201/eid1509.090497. View

12.

Parashar U, Burton A, Lanata C, Boschi-Pinto C, Shibuya K, Steele D . Global mortality associated with rotavirus disease among children in 2004. J Infect Dis. 2009; 200 Suppl 1:S9-S15. DOI: 10.1086/605025. View

13.

Ndze V, Papp H, Achidi E, Gonsu K, Laszlo B, Farkas S . One year survey of human rotavirus strains suggests the emergence of genotype G12 in Cameroon. J Med Virol. 2013; 85(8):1485-90. PMC: 8167840. DOI: 10.1002/jmv.23603. View

14.

Seheri M, Nemarude L, Peenze I, Netshifhefhe L, Nyaga M, Ngobeni H . Update of rotavirus strains circulating in Africa from 2007 through 2011. Pediatr Infect Dis J. 2013; 33 Suppl 1:S76-84. DOI: 10.1097/INF.0000000000000053. View

15.

Cunliffe N, Ngwira B, Dove W, Nakagomi O, Nakagomi T, Perez A . Serotype g12 rotaviruses, Lilongwe, Malawi. Emerg Infect Dis. 2009; 15(1):87-90. PMC: 2660691. DOI: 10.3201/eid1501.080427. View

16.

Gomez M, Resque H, Volotao E, Rose T, da Silva M, Heylen E . Distinct evolutionary origins of G12P[8] and G12P[9] group A rotavirus strains circulating in Brazil. Infect Genet Evol. 2014; 28:385-8. DOI: 10.1016/j.meegid.2014.04.007. View

17.

Arista S, Vizzi E, Alaimo C, Palermo D, Cascio A . Identification of human rotavirus strains with the P[14] genotype by PCR. J Clin Microbiol. 1999; 37(8):2706-8. PMC: 85321. DOI: 10.1128/JCM.37.8.2706-2708.1999. View

18.

Rahman M, Matthijnssens J, Yang X, Delbeke T, Arijs I, Taniguchi K . Evolutionary history and global spread of the emerging g12 human rotaviruses. J Virol. 2006; 81(5):2382-90. PMC: 1865926. DOI: 10.1128/JVI.01622-06. View

19.

Mandile M, Esteban L, Arguelles M, Mistchenko A, Glikmann G, Castello A . Surveillance of group A Rotavirus in Buenos Aires 2008-2011, long lasting circulation of G2P[4] strains possibly linked to massive monovalent vaccination in the region. J Clin Virol. 2014; 60(3):282-9. DOI: 10.1016/j.jcv.2014.04.022. View

20.

Mwenda J, Ntoto K, Abebe A, Enweronu-Laryea C, Amina I, Mchomvu J . Burden and epidemiology of rotavirus diarrhea in selected African countries: preliminary results from the African Rotavirus Surveillance Network. J Infect Dis. 2010; 202 Suppl:S5-S11. DOI: 10.1086/653557. View