Application of a Wide-field Phantom Eye for Optical Coherence Tomography and Reflectance Imaging

Overview

Journal J Mod Opt

Date 2016 Jan 8

PMID 26740737

Citations 7

Authors

Anthony Corcoran

Gonzalo Muyo

Jano van Hemert

Alistair Gorman

Andrew R Harvey

Affiliations

Soon will be listed here.

Abstract

Optical coherence tomography (OCT) and reflectance imaging are used in clinical practice to measure the thickness and transverse dimensions of retinal features. The recent trend towards increasing the field of view (FOV) of these devices has led to an increasing significance of the optical aberrations of both the human eye and the device. We report the design, manufacture and application of the first phantom eye that reproduces the off-axis optical characteristics of the human eye, and allows the performance assessment of wide-field ophthalmic devices. We base our design and manufacture on the wide-field schematic eye, [Navarro, R. , .] as an accurate proxy to the human eye and enable assessment of ophthalmic imaging performance for a [Formula: see text] external FOV. We used multi-material 3D-printed retinal targets to assess imaging performance of the following ophthalmic instruments: the Optos 200Tx, Heidelberg Spectralis, Zeiss FF4 fundus camera and Optos and use the phantom to provide an insight into some of the challenges of wide-field OCT.

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References

Pogue B, Patterson M . Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry. J Biomed Opt. 2006; 11(4):041102. DOI: 10.1117/1.2335429. View

Manivannan A, Plskova J, Farrow A, McKay S, Sharp P, Forrester J . Ultra-wide-field fluorescein angiography of the ocular fundus. Am J Ophthalmol. 2005; 140(3):525-7. DOI: 10.1016/j.ajo.2005.02.055. View

Curatolo A, Kennedy B, Sampson D . Structured three-dimensional optical phantom for optical coherence tomography. Opt Express. 2011; 19(20):19480-5. DOI: 10.1364/OE.19.019480. View

Agrawal A, Chen C, Baxi J, Chen Y, Pfefer T . Multilayer thin-film phantoms for axial contrast transfer function measurement in optical coherence tomography. Biomed Opt Express. 2013; 4(7):1166-75. PMC: 3704096. DOI: 10.1364/BOE.4.001166. View

Mordant D, Al-Abboud I, Muyo G, Gorman A, Sallam A, Rodmell P . Validation of human whole blood oximetry, using a hyperspectral fundus camera with a model eye. Invest Ophthalmol Vis Sci. 2011; 52(5):2851-9. DOI: 10.1167/iovs.10-6217. View

Baxi J, Calhoun W, Sepah Y, Hammer D, Ilev I, Pfefer T . Retina-simulating phantom for optical coherence tomography. J Biomed Opt. 2013; 19(2):21106. DOI: 10.1117/1.JBO.19.2.021106. View

Seidensticker F, Neubauer A, Wasfy T, Stumpf C, Thurau S, Kampik A . Wide-field fundus autofluorescence corresponds to visual fields in chorioretinitis patients. Clin Ophthalmol. 2011; 5:1667-71. PMC: 3236712. DOI: 10.2147/OPTH.S26224. View

Silva P, Cavallerano J, Tolls D, Omar A, Thakore K, Patel B . Potential efficiency benefits of nonmydriatic ultrawide field retinal imaging in an ocular telehealth diabetic retinopathy program. Diabetes Care. 2013; 37(1):50-5. DOI: 10.2337/dc13-1292. View

Wang J, Coburn J, Liang C, Woolsey N, Ramella-Roman J, Chen Y . Three-dimensional printing of tissue phantoms for biophotonic imaging. Opt Lett. 2014; 39(10):3010-3. DOI: 10.1364/OL.39.003010. View

10.

Agrawal A, Connors M, Beylin A, Liang C, Barton D, Chen Y . Characterizing the point spread function of retinal OCT devices with a model eye-based phantom. Biomed Opt Express. 2012; 3(5):1116-26. PMC: 3342187. DOI: 10.1364/BOE.3.0011163. View

11.

Wolf-Schnurrbusch U, Ceklic L, Brinkmann C, Iliev M, Frey M, Rothenbuehler S . Macular thickness measurements in healthy eyes using six different optical coherence tomography instruments. Invest Ophthalmol Vis Sci. 2009; 50(7):3432-7. DOI: 10.1167/iovs.08-2970. View

12.

Goncharov A, Dainty C . Wide-field schematic eye models with gradient-index lens. J Opt Soc Am A Opt Image Sci Vis. 2007; 24(8):2157-74. DOI: 10.1364/josaa.24.002157. View

13.

de Bruin D, Bremmer R, Kodach V, de Kinkelder R, van Marle J, van Leeuwen T . Optical phantoms of varying geometry based on thin building blocks with controlled optical properties. J Biomed Opt. 2010; 15(2):025001. DOI: 10.1117/1.3369003. View

14.

Fernandez E, Artal P . Dynamic eye model for adaptive optics testing. Appl Opt. 2007; 46(28):6971-7. DOI: 10.1364/ao.46.006971. View

15.

Soliman A, Silva P, Aiello L, Sun J . Ultra-wide field retinal imaging in detection, classification, and management of diabetic retinopathy. Semin Ophthalmol. 2012; 27(5-6):221-7. DOI: 10.3109/08820538.2012.708812. View

16.

Bakaraju R, Ehrmann K, Papas E, Ho A . Finite schematic eye models and their accuracy to in-vivo data. Vision Res. 2008; 48(16):1681-1694. DOI: 10.1016/j.visres.2008.04.009. View

17.

Seibold L, Mandava N, Kahook M . Comparison of retinal nerve fiber layer thickness in normal eyes using time-domain and spectral-domain optical coherence tomography. Am J Ophthalmol. 2010; 150(6):807-14. DOI: 10.1016/j.ajo.2010.06.024. View

18.

Sayegh R, Simader C, Scheschy U, Montuoro A, Kiss C, Sacu S . A systematic comparison of spectral-domain optical coherence tomography and fundus autofluorescence in patients with geographic atrophy. Ophthalmology. 2011; 118(9):1844-51. DOI: 10.1016/j.ophtha.2011.01.043. View

19.

Nguyen T, Le H, Vo M, Wang Z, Luu L, Ramella-Roman J . Three-dimensional phantoms for curvature correction in spatial frequency domain imaging. Biomed Opt Express. 2012; 3(6):1200-14. PMC: 3370962. DOI: 10.1364/BOE.3.001200. View

20.

Wojtkowski M . High-speed optical coherence tomography: basics and applications. Appl Opt. 2010; 49(16):D30-61. DOI: 10.1364/AO.49.000D30. View