Are Itch and Scratching the Nausea and Vomiting of Skin?

Overview

Journal Exp Dermatol

Specialty Dermatology

Date 2016 Jan 8

PMID 26739556

Citations 2

Authors

Sattar Ostadhadi

Ehsan Azimi

Ethan A Lerner

Ahmad-Reza Dehpour

Affiliations

Soon will be listed here.

Abstract

The physiologic similarities between itch and nausea may not be evident initially, but they share the role of repelling irritants and toxins from the body by inducting scratching and vomiting, respectively. In addition, itch and nausea frequently occur together in certain conditions such as uraemia. Here we show that the mechanisms underlying itch and nausea overlap and that advances in either field may influence the identification of novel drug targets, particularly for itch.

Citing Articles

Physiology and Pathophysiology of Itch.

Cevikbas F, Lerner E Physiol Rev. 2019; 100(3):945-982.

PMID: 31869278 PMC: 7474262. DOI: 10.1152/physrev.00017.2019.

The brain-penetrating, orally bioavailable, ghrelin receptor agonist HM01 ameliorates motion-induced emesis in Suncus murinus (house musk shrew).

Tu L, Lu Z, Ngan M, Lam F, Giuliano C, Lovati E Br J Pharmacol. 2019; 177(7):1635-1650.

PMID: 31722444 PMC: 7060360. DOI: 10.1111/bph.14924.

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