Detrimental or Beneficial: the Role of TRPM2 in Ischemia/reperfusion Injury

Overview

Journal Acta Pharmacol Sin

Specialty Pharmacology

Date 2016 Jan 5

PMID 26725732

Citations 19

Authors

Kai-yu Zhan

Pei-Lin Yu

Chun-Hui Liu

Jian-Hong Luo

Wei Yang

Affiliations

Soon will be listed here.

Abstract

Ischemia/reperfusion (I/R) injury is the main cause of tissue damage and dysfunction. I/R injury is characterized by Ca(2+) overload and production of reactive oxygen species (ROS), which play critical roles in the process of I/R injury to the brain, heart and kidney, but the underlying mechanisms are largely elusive. Recent evidence demonstrates that TRPM2, a Ca(2+)-permeable cationic channel and ROS sensor, is involved in I/R injury, but whether TRPM2 plays a protective or detrimental role in this process remains controversial. In this review, we discuss the recent progress in understanding the role of TRPM2 in reperfusion process after brain, heart and kidney ischemia and the potential of targeting TRPM2 for the development of therapeutic drugs to treat I/R injury.

Citing Articles

Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms.

Huang J, Korsunsky A, Yazdani M, Chen J Front Mol Neurosci. 2024; 16:1334370.

PMID: 38273937 PMC: 10808746. DOI: 10.3389/fnmol.2023.1334370.

TRPM2: bridging calcium and ROS signaling pathways-implications for human diseases.

Maliougina M, Hiani Y Front Physiol. 2023; 14:1217828.

PMID: 37576339 PMC: 10412822. DOI: 10.3389/fphys.2023.1217828.

TRPM2 Mediates Hepatic Ischemia-Reperfusion Injury via Ca-Induced Mitochondrial Lipid Peroxidation through Increasing ALOX12 Expression.

Zhong C, Yang J, Zhang Y, Fan X, Fan Y, Hua N Research (Wash D C). 2023; 6:0159.

PMID: 37275121 PMC: 10232356. DOI: 10.34133/research.0159.

Effects of Apocynin, a NADPH Oxidase Inhibitor, in the Protection of the Heart from Ischemia/Reperfusion Injury.

Mohammad A, Babiker F, Al-Bader M Pharmaceuticals (Basel). 2023; 16(4).

PMID: 37111249 PMC: 10141704. DOI: 10.3390/ph16040492.

Research Progress on the Role of Pyroptosis in Myocardial Ischemia-Reperfusion Injury.

Liu Y, Zhang J, Zhang D, Yu P, Zhang J, Yu S Cells. 2022; 11(20).

PMID: 36291138 PMC: 9601171. DOI: 10.3390/cells11203271.

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