Pathologic Changes of Wound Tissue in Rats with Stage III Pressure Ulcers Treated by Transplantation of Human Amniotic Epithelial Cells

Overview

Journal Int J Clin Exp Pathol

Specialty Pathology

Date 2016 Jan 2

PMID 26722414

Citations 3

Authors

Xilan Zheng

Zhixia Jiang

Aiting Zhou

Limei Yu

Mingtao Quan

Huagang Cheng

Affiliations

Soon will be listed here.

Abstract

This study aims to determine the impact of orthotopic transplantation of human amniotic epithelial cells (hAECs) on the pathologic changes of wound tissues in a self-prepared rat stage III pressure ulcer model. Ninety-six SD rats were randomly divided into the model group (group M), hAEC transplantation group (group H), traditional treatment group (group T), and the control group (group C), with 24 rats in each group. The wound healing time was observed in 6 rats from each group, and 6 rats of each group were selected for post-modeling on day(s) (D) 1, 3, and 7 for HE staining to compare the pathological changes. The healing time of group H was significantly shorter than the other three groups. Moreover, pathological observations revealed that group H exhibited significant proliferation of fibrous tissues and vessels in the dermal layer, and the appearance time and degree of skin appendages were significantly greater than that observed in the other three groups. Pathological observations showed that hAEC transplantation could significantly speed up the healing of stage III pressure ulcer.

Citing Articles

Human Amniotic Epithelial Stem Cells Promote Colonic Recovery in Experimental Colitis via Exosomal MiR-23a-TNFR1-NF-κB Signaling.

Kou Y, Li J, Zhu Y, Liu J, Ren R, Jiang Y Adv Sci (Weinh). 2024; 11(44):e2401429.

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Mesenchymal Stromal Cell Healing Outcomes in Clinical and Pre-Clinical Models to Treat Pressure Ulcers: A Systematic Review.

Torres-Guzman R, Avila F, Maita K, Garcia J, Sario G, Borna S J Clin Med. 2023; 12(24).

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Application of human amniotic epithelial cells in regenerative medicine: a systematic review.

Zhang Q, Lai D Stem Cell Res Ther. 2020; 11(1):439.

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