Role of Kv4.3 in Vibration-Induced Muscle Pain in the Rat

Overview

Journal J Pain

Specialties Neurology
Psychiatry

Date 2016 Jan 2

PMID 26721612

Citations 12

Authors

Lindsay B Conner

Pedro Alvarez

Oliver Bogen

Jon D Levine

Affiliations

Soon will be listed here.

Abstract

Unlabelled: We hypothesized that changes in the expression of voltage-gated potassium channel (Kv) 4.3 contribute to the mechanical hyperalgesia induced by vibration injury, in a rodent model for hand-arm vibration syndrome in humans. Here we show that the exposure of the gastrocnemius muscle to vibration injury induces muscle hyperalgesia that is accompanied by a significant downregulation of Kv4.3 in affected sensory nerve fibers in dorsal root ganglia. We additionally show that the intrathecal administration of antisense oligonucleotides for Kv4.3 messenger RNA itself induces muscle hyperalgesia in the rat. Our results suggest that attenuation in the expression of Kv4.3 may contribute to neuropathic pain in people affected by hand-arm vibration syndrome.

Perspective: Our findings establish Kv4.3 as a potential molecular target for the treatment of hand-arm vibration syndrome.

Citing Articles

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K4 channels in isolectin B4 muscle dorsal root ganglion neurons of rats with experimental peripheral artery disease: effects of bradykinin B1 and B2 receptors.

Li Q, Qin L, Li J Am J Physiol Regul Integr Comp Physiol. 2022; 323(5):R616-R627.

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Effects of bradykinin on voltage-gated K 4 channels in muscle dorsal root ganglion neurons of rats with experimental peripheral artery disease.

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