Cancer Stem Cells and Signaling Pathways in Radioresistance

Overview

Journal Oncotarget

Specialty Oncology

Date 2015 Dec 31

PMID 26716904

Citations 67

Authors

Lei Chang

Peter Graham

Jingli Hao

Jie Ni

Junli Deng

Joseph Bucci

David Malouf

David Gillatt

Yong Li

Affiliations

Soon will be listed here.

Abstract

Radiation therapy (RT) is one of the most important strategies in cancer treatment. Radioresistance (the failure to RT) results in locoregional recurrence and metastasis. Therefore, it is critically important to investigate the mechanisms leading to cancer radioresistance to overcome this problem and increase patients' survival. Currently, the majority of the radioresistance-associated researches have focused on preclinical studies. Although the exact mechanisms of cancer radioresistance have not been fully uncovered, accumulating evidence supports that cancer stem cells (CSCs) and different signaling pathways play important roles in regulating radiation response and radioresistance. Therefore, targeting CSCs or signaling pathway proteins may hold promise for developing novel combination modalities and overcoming radioresistance. The present review focuses on the key evidence of CSC markers and several important signaling pathways in cancer radioresistance and explores innovative approaches for future radiation treatment.

Citing Articles

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Aldo-keto reductase family 1 member C3 mediates radioresistance of esophageal cancer cells through suppressing MAPK and AKT signaling.

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Cancer radioresistance is characterized by a differential lipid droplet content along the cell cycle.

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