The Effects of Caffeine Supplements on Exercise-Induced Oxidative Damages

Overview

Journal Asian J Sports Med

Publisher Brieflands

Specialty Orthopedics

Date 2015 Dec 31

PMID 26715963

Citations 5

Authors

Akbar Zeraatpishe

Ali Akbar Malekirad

Javad Nik-Kherad

Afshar Jafari

Saeed Yousefi Babadi

Farzeen Tanwir

Hamid Reza Espanani

Affiliations

Soon will be listed here.

Abstract

Background: There is an interaction between oxidative equilibrium and anti-oxidants in oxidative stress. Therefore, oxidative stress has an effect on intercellular oxidation and causes atrophy and is an underlying factor in many diseases.

Objectives: The aim of this study was to investigate the effect of running downhill and the short-term effect of caffeine supplementation on oxidative stress in non-athletic men.

Patients And Methods: Twenty men, aged 25 - 28 years, from Tabriz, Iran were been selected and divided in two homogeneous groups of 10 men: the supplementation group and the placebo group. In the next stage, groups received caffeine supplementation (caffeine capsules at a dose of 5 mg/kg of body weight daily for 14 days) or placebo (5 mg/kg of dextrose during supplementation) and ran downhill (30 minutes of treadmill running with a slope of -10 degrees with 65% maximal oxygen consumption); blood sampling was also performed.

Results: Anti-oxidant capacity by the ferric reducing ability of plasma (FRAP) techniques and serum malondialdehyde (MDA) were measured by the thiobarbituric acid (TBA) method, while the total number of thiol molecules (TTM) with Hu and DNA damage was evaluated using ELISA.

Conclusions: The results of this study indicated that running downhill caused significant changes in all measured parameters, but the short-term caffeine supplementation did not have a significant effect on the indices of oxidative stress or DNA damage measured.

Citing Articles

The Potential Benefit of Monitoring Oxidative Stress and Inflammation in the Prevention of Non-Communicable Diseases (NCDs).

Seyedsadjadi N, Grant R Antioxidants (Basel). 2020; 10(1).

PMID: 33375428 PMC: 7824370. DOI: 10.3390/antiox10010015.

Tea consumption and oxidative stress: a cross-sectional analysis of 889 premenopausal women from the Sister Study.

Zhang D, Ferguson K, Troester M, Bensen J, Cai J, Milne G Br J Nutr. 2018; 121(5):582-590.

PMID: 30567620 PMC: 6586547. DOI: 10.1017/S0007114518003732.

Significant relationships between a simple marker of redox balance and lifestyle behaviours; Relevance to the Framingham risk score.

Seyedsadjadi N, Berg J, Bilgin A, Tung C, Grant R PLoS One. 2017; 12(11):e0187713.

PMID: 29107974 PMC: 5673171. DOI: 10.1371/journal.pone.0187713.

THE EFFECT OF CAFFEINE SUPPLEMENTATION ON TRAINED INDIVIDUALS SUBJECTED TO MAXIMAL TREADMILL TEST.

Salicio V, Fett C, Salicio M, Brandao C, Stoppiglia L, Fett W Afr J Tradit Complement Altern Med. 2017; 14(1):16-23.

PMID: 28480382 PMC: 5411867. DOI: 10.21010/ajtcam.v14i1.3.

Rhein exhibits antioxidative effects similar to Rhubarb in a rat model of traumatic brain injury.

Xu X, Lv H, Xia Z, Fan R, Zhang C, Wang Y BMC Complement Altern Med. 2017; 17(1):140.

PMID: 28264680 PMC: 5340037. DOI: 10.1186/s12906-017-1655-x.

References

Olcina G, Munoz D, Timon R, Caballero M, Maynar J, Cordova A . Effect of caffeine on oxidative stress during maximum incremental exercise. J Sports Sci Med. 2013; 5(4):621-8. PMC: 3861764. View

Nikolic J, Bjelakovic G, Stojanovic I . Effect of caffeine on metabolism of L-arginine in the brain. Mol Cell Biochem. 2003; 244(1-2):125-8. View

Barcelos R, Souza M, Amaral G, Stefanello S, Bresciani G, Fighera M . Caffeine supplementation modulates oxidative stress markers in the liver of trained rats. Life Sci. 2013; 96(1-2):40-5. DOI: 10.1016/j.lfs.2013.12.002. View

Lee C . Antioxidant ability of caffeine and its metabolites based on the study of oxygen radical absorbing capacity and inhibition of LDL peroxidation. Clin Chim Acta. 2000; 295(1-2):141-54. DOI: 10.1016/s0009-8981(00)00201-1. View

Shi X, Dalal N, Jain A . Antioxidant behaviour of caffeine: efficient scavenging of hydroxyl radicals. Food Chem Toxicol. 1991; 29(1):1-6. DOI: 10.1016/0278-6915(91)90056-d. View

Corsetti G, Pasini E, Assanelli D, Saligari E, Adobati M, Bianchi R . Acute caffeine administration decreased NOS and Bcl2 expression in rat skeletal muscles. Pharmacol Res. 2007; 55(2):96-103. DOI: 10.1016/j.phrs.2006.10.001. View

Cheung K, Hume P, Maxwell L . Delayed onset muscle soreness : treatment strategies and performance factors. Sports Med. 2003; 33(2):145-64. DOI: 10.2165/00007256-200333020-00005. View

Mukhopadhyay S, Mondal A, Poddar M . Chronic administration of caffeine: effect on the activities of hepatic antioxidant enzymes of Ehrlich ascites tumor-bearing mice. Indian J Exp Biol. 2004; 41(4):283-9. View

Hotta N, Sato K, Sun Z, Katayama K, Akima H, Kondo T . Ventilatory and circulatory responses at the onset of exercise after eccentric exercise. Eur J Appl Physiol. 2006; 97(5):598-606. DOI: 10.1007/s00421-006-0212-y. View

10.

Beck T, Housh T, Schmidt R, Johnson G, Housh D, Coburn J . The acute effects of a caffeine-containing supplement on strength, muscular endurance, and anaerobic capabilities. J Strength Cond Res. 2006; 20(3):506-10. DOI: 10.1519/18285.1. View

11.

Varma S, Hegde K, Kovtun S . Oxidative stress in lens in vivo: inhibitory effect of caffeine. A preliminary report. Mol Vis. 2010; 16:501-5. PMC: 2845664. View

12.

Devasagayam T, Kamat J, Mohan H, Kesavan P . Caffeine as an antioxidant: inhibition of lipid peroxidation induced by reactive oxygen species. Biochim Biophys Acta. 1996; 1282(1):63-70. DOI: 10.1016/0005-2736(96)00040-5. View

13.

Prasanthi J, Dasari B, Marwarha G, Larson T, Chen X, Geiger J . Caffeine protects against oxidative stress and Alzheimer's disease-like pathology in rabbit hippocampus induced by cholesterol-enriched diet. Free Radic Biol Med. 2010; 49(7):1212-20. PMC: 2930139. DOI: 10.1016/j.freeradbiomed.2010.07.007. View

14.

Barcelos R, Souza M, Amaral G, Stefanello S, Bresciani G, Fighera M . Caffeine intake may modulate inflammation markers in trained rats. Nutrients. 2014; 6(4):1678-90. PMC: 4011059. DOI: 10.3390/nu6041678. View

15.

Bruce C, Yates D, Thomas P . Caffeine decreases exhaled nitric oxide. Thorax. 2002; 57(4):361-3. PMC: 1746303. DOI: 10.1136/thorax.57.4.361. View