Intranasal Inoculation of Sows with Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus at Mid-gestation Causes Transplacental Infection of Fetuses

Overview

Journal Vet Res

Publisher Biomed Central

Specialty Veterinary Medicine

Date 2015 Dec 31

PMID 26715184

Citations 2

Authors

Tongtong Wang

Xiaofei Wang

Xin-An Li

Li Nie

Minxia Zhang

Sidang Liu

Xiaomin Zhao

Yingli Shang

En-Min Zhou

Julian A Hiscox

Yihong Xiao

Affiliations

Soon will be listed here.

Abstract

Transplacental infection plays a critical role in the reproductive failure induced by porcine reproductive and respiratory syndrome virus (PRRSV), yet exposure of sows and gilts to classical PRRSV generally leads to reproductive failure after 85 days of gestation. We report, for the first time, that the susceptibility of fetuses to highly pathogenic PRRSV (HP-PRRSV) is similar at 60 days and 90 days of gestation. This difference from classical PRRSV may contribute to its high pathogenicity. A field study of the HP-PRRSV vaccine in pregnant sows at mid-gestation should be considered.

Citing Articles

The tail domain of PRRSV NSP2 plays a key role in aggrephagy by interacting with 14-3-3ε.

Cao S, Liu J, Ding G, Shao Q, Wang B, Li Y Vet Res. 2020; 51(1):104.

PMID: 32811532 PMC: 7433210. DOI: 10.1186/s13567-020-00816-7.

Porcine Reproductive and Respiratory Syndrome Virus Structural Protein GP3 Regulates Claudin 4 To Facilitate the Early Stages of Infection.

Ding G, Liu J, Shao Q, Wang B, Feng J, Li Y J Virol. 2020; 94(20).

PMID: 32759320 PMC: 7527063. DOI: 10.1128/JVI.00124-20.

References

Nielsen J, Botner A, Bille-Hansen V, Oleksiewicz M, Storgaard T . Experimental inoculation of late term pregnant sows with a field isolate of porcine reproductive and respiratory syndrome vaccine-derived virus. Vet Microbiol. 2001; 84(1-2):1-13. PMC: 7117428. DOI: 10.1016/s0378-1135(01)00450-3. View

Zhou L, Yang H . Porcine reproductive and respiratory syndrome in China. Virus Res. 2010; 154(1-2):31-7. DOI: 10.1016/j.virusres.2010.07.016. View

Wang X, Qiu H, Zhang M, Cai X, Qu Y, Hu D . Distribution of highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) in different stages of gestation sows: HP-PRRSV distribution in gestation sows. Vet Immunol Immunopathol. 2015; 166(3-4):88-94. DOI: 10.1016/j.vetimm.2015.06.002. View

Johnson C, Griggs T, Gnanandarajah J, Murtaugh M . Novel structural protein in porcine reproductive and respiratory syndrome virus encoded by an alternative ORF5 present in all arteriviruses. J Gen Virol. 2011; 92(Pt 5):1107-1116. PMC: 3139420. DOI: 10.1099/vir.0.030213-0. View

Scortti M, Prieto C, Martinez-Lobo F, Simarro I, Castro J . Effects of two commercial European modified-live vaccines against porcine reproductive and respiratory syndrome viruses in pregnant gilts. Vet J. 2005; 172(3):506-14. DOI: 10.1016/j.tvjl.2005.07.015. View

Christianson W, Choi C, Collins J, Molitor T, Morrison R, Joo H . Pathogenesis of porcine reproductive and respiratory syndrome virus infection in mid-gestation sows and fetuses. Can J Vet Res. 1993; 57(4):262-8. PMC: 1263638. View

Lager K, Mengeling W, Brockmeier S . Evaluation of protective immunity in gilts inoculated with the NADC-8 isolate of porcine reproductive and respiratory syndrome virus (PRRSV) and challenge-exposed with an antigenically distinct PRRSV isolate. Am J Vet Res. 1999; 60(8):1022-7. View

Prieto C, Suarez P, Simarro I, Garcia C, Fernandez A, Castro J . Transplacental infection following exposure of gilts to porcine reproductive and respiratory syndrome virus at the onset of gestation. Vet Microbiol. 1998; 57(4):301-11. DOI: 10.1016/s0378-1135(97)00112-0. View

Wassenaar A, Spaan W, Gorbalenya A, Snijder E . Alternative proteolytic processing of the arterivirus replicase ORF1a polyprotein: evidence that NSP2 acts as a cofactor for the NSP4 serine protease. J Virol. 1997; 71(12):9313-22. PMC: 230234. DOI: 10.1128/JVI.71.12.9313-9322.1997. View

10.

Tian K, Yu X, Zhao T, Feng Y, Cao Z, Wang C . Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark. PLoS One. 2007; 2(6):e526. PMC: 1885284. DOI: 10.1371/journal.pone.0000526. View

11.

Karniychuk U, Nauwynck H . Quantitative changes of sialoadhesin and CD163 positive macrophages in the implantation sites and organs of porcine embryos/fetuses during gestation. Placenta. 2009; 30(6):497-500. DOI: 10.1016/j.placenta.2009.03.016. View

12.

Karniychuk U, De Spiegelaere W, Nauwynck H . Porcine reproductive and respiratory syndrome virus infection is associated with an increased number of Sn-positive and CD8-positive cells in the maternal-fetal interface. Virus Res. 2013; 176(1-2):285-91. DOI: 10.1016/j.virusres.2013.05.005. View

13.

Feng Y, Zhao T, Nguyen T, Inui K, Ma Y, Nguyen T . Porcine respiratory and reproductive syndrome virus variants, Vietnam and China, 2007. Emerg Infect Dis. 2008; 14(11):1774-6. PMC: 2630730. DOI: 10.3201/eid1411.071676. View

14.

An T, Tian Z, Xiao Y, Li R, Peng J, Wei T . Origin of highly pathogenic porcine reproductive and respiratory syndrome virus, China. Emerg Infect Dis. 2010; 16(2):365-7. PMC: 2957991. DOI: 10.3201/eid1602.090005. View

15.

Tong G, Zhou Y, Hao X, Tian Z, An T, Qiu H . Highly pathogenic porcine reproductive and respiratory syndrome, China. Emerg Infect Dis. 2008; 13(9):1434-6. PMC: 2857295. DOI: 10.3201/eid1309.070399. View

16.

Van Gorp H, Van Breedam W, Delputte P, Nauwynck H . Sialoadhesin and CD163 join forces during entry of the porcine reproductive and respiratory syndrome virus. J Gen Virol. 2008; 89(Pt 12):2943-2953. DOI: 10.1099/vir.0.2008/005009-0. View

17.

Rowland R . The interaction between PRRSV and the late gestation pig fetus. Virus Res. 2010; 154(1-2):114-22. PMC: 7172144. DOI: 10.1016/j.virusres.2010.09.001. View

18.

Kranker S, Nielsen J, Bille-Hansen V, Botner A . Experimental inoculation of swine at various stages of gestation with a Danish isolate of porcine reproductive and respiratory syndrome virus (PRRSV). Vet Microbiol. 1998; 61(1-2):21-31. DOI: 10.1016/s0378-1135(98)00176-x. View

19.

Prieto C, Suarez P, Martin-Rillo S, Simarro I, Solana A, Castro J . Effect of porcine reproductive and respiratory syndrome virus (PRRSV) on development of porcine fertilized ova in vitro. Theriogenology. 1996; 46(4):687-93. DOI: 10.1016/0093-691X(96)00220-8. View

20.

Snijder E, Wassenaar A, Spaan W, Gorbalenya A . The arterivirus Nsp2 protease. An unusual cysteine protease with primary structure similarities to both papain-like and chymotrypsin-like proteases. J Biol Chem. 1995; 270(28):16671-6. DOI: 10.1074/jbc.270.28.16671. View