APOH Interacts with FTO to Predispose to Healthy Thinness

Overview

Journal Hum Genet

Specialty Genetics

Date 2015 Dec 30

PMID 26711810

Citations 6

Authors

Sandra J Hasstedt

Hilary Coon

Yuanpei Xin

Ted D Adams

Steven C Hunt

Affiliations

Soon will be listed here.

Abstract

We identified eight candidate thinness predisposition variants from the Illumina HumanExome chip genotyped on members of pedigrees selected for either healthy thinness or severe obesity. For validation, we tested the candidates for association with healthy thinness in additional pedigree members while accounting for effects of obesity-associated genes: NPFFR2, NPY2R, FTO, and MC4R. Significance was obtained for the interaction of FTO rs9939609 with APOH missense variant rs52797880 (minor allele frequency 0.054). The thinness odds ratio was estimated as 2.15 (p < 0.05) for the combination of APOH heterozygote with the homozygote for the non-obesity FTO allele. Significance was not obtained for any other combination of a candidate variant with an obesity gene or for any of the eight candidates tested independently.

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