Correlation Between Parameters of Calcaneal Quantitative Ultrasound and Hip Structural Analysis in Osteoporotic Fracture Patients

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Dec 29

PMID 26710123

Citations 9

Authors

Licheng Zhang

Houchen Lv

Hailiang Zheng

Ming Li

Pengbin Yin

Ye Peng

Yuan Gao

Lihai Zhang

Peifu Tang

Affiliations

Soon will be listed here.

Abstract

Background: Calcaneal quantitative ultrasound (QUS), which is used in the evaluation of osteoporosis, is believed to be intimately associated with the characteristics of the proximal femur. However, the specific associations of calcaneal QUS with characteristics of the hip sub-regions remain unclear.

Design: A cross-sectional assessment of 53 osteoporotic patients was performed for the skeletal status of the heel and hip.

Methods: We prospectively enrolled 53 female osteoporotic patients with femoral fractures. Calcaneal QUS, dual energy X-ray absorptiometry (DXA), and hip structural analysis (HSA) were performed for each patient. Femoral heads were obtained during the surgery, and principal compressive trabeculae (PCT) were extracted by a three-dimensional printing technique-assisted method. Pearson's correlation between QUS measurement with DXA, HSA-derived parameters and Young's modulus were calculated in order to evaluate the specific association of QUS with the parameters for the hip sub-regions, including the femoral neck, trochanteric and Ward's areas, and the femoral shaft, respectively.

Results: Significant correlations were found between estimated BMD (Est.BMD) and BMD of different sub-regions of proximal femur. However, the correlation coefficient of trochanteric area (r = 0.356, p = 0.009) was higher than that of the neck area (r = 0.297, p = 0.031) and total proximal femur (r = 0.291, p = 0.034). Furthermore, the quantitative ultrasound index (QUI) was significantly correlated with the HSA-derived parameters of the trochanteric area (r value: 0.315-0.356, all p<0.05) as well as with the Young's modulus of PCT from the femoral head (r = 0.589, p<0.001).

Conclusion: The calcaneal bone had an intimate association with the trochanteric cancellous bone. To a certain extent, the parameters of the calcaneal QUS can reflect the characteristics of the trochanteric area of the proximal hip, although not specifically reflective of those of the femoral neck or shaft.

Citing Articles

Quantitative Ultrasound and Bone Health in Elderly People, a Systematic Review.

Escobio-Prieto I, Blanco-Diaz M, Pinero-Pinto E, Rodriguez-Rodriguez A, Ruiz-Dorantes F, Albornoz-Cabello M Biomedicines. 2023; 11(4).

PMID: 37189793 PMC: 10135977. DOI: 10.3390/biomedicines11041175.

Living alone decreased calcaneus ultrasound -score in a large Taiwanese population follow-up study.

Lin T, Chen S, Geng J, Tsai H Front Public Health. 2022; 10:1004794.

PMID: 36276395 PMC: 9581291. DOI: 10.3389/fpubh.2022.1004794.

Analysis of Calcaneal Bone Mineral Density (cBMD) in Healthy College Students.

Bennett J, Austin T, Hayes A, Reinking M Int J Sports Phys Ther. 2022; 17(2):218-227.

PMID: 35136691 PMC: 8805111. DOI: 10.26603/001c.31653.

Radiofrequency echographic multi-spectrometry for the in-vivo assessment of bone strength: state of the art-outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis....

Diez-Perez A, Brandi M, Al-Daghri N, Branco J, Bruyere O, Cavalli L Aging Clin Exp Res. 2019; 31(10):1375-1389.

PMID: 31422565 PMC: 6763416. DOI: 10.1007/s40520-019-01294-4.

Quantitative ultrasonometry: An alternative and easy method to evaluate bone quality in people living with human immunodeficiency virus.

Segal E, Hassoun G, Maor C, Shahar E J Musculoskelet Neuronal Interact. 2019; 19(1):112-117.

PMID: 30839309 PMC: 6454262.

References

Center J, Bliuc D, Nguyen T, Eisman J . Risk of subsequent fracture after low-trauma fracture in men and women. JAMA. 2007; 297(4):387-94. DOI: 10.1001/jama.297.4.387. View

Nguyen N, Ahlborg H, Center J, Eisman J, Nguyen T . Residual lifetime risk of fractures in women and men. J Bone Miner Res. 2007; 22(6):781-8. DOI: 10.1359/jbmr.070315. View

Trimpou P, Bosaeus I, Bengtsson B, Landin-Wilhelmsen K . High correlation between quantitative ultrasound and DXA during 7 years of follow-up. Eur J Radiol. 2009; 73(2):360-4. DOI: 10.1016/j.ejrad.2008.11.024. View

Maeda Y, Sugano N, Saito M, Yonenobu K . Comparison of femoral morphology and bone mineral density between femoral neck fractures and trochanteric fractures. Clin Orthop Relat Res. 2010; 469(3):884-9. PMC: 3032853. DOI: 10.1007/s11999-010-1529-8. View

Morin S, Lix L, Azimaee M, Metge C, Caetano P, Leslie W . Mortality rates after incident non-traumatic fractures in older men and women. Osteoporos Int. 2010; 22(9):2439-48. DOI: 10.1007/s00198-010-1480-2. View

Moayyeri A, Adams J, Adler R, Krieg M, Hans D, Compston J . Quantitative ultrasound of the heel and fracture risk assessment: an updated meta-analysis. Osteoporos Int. 2011; 23(1):143-53. DOI: 10.1007/s00198-011-1817-5. View

Chan M, Nguyen N, Center J, Eisman J, Nguyen T . Absolute fracture-risk prediction by a combination of calcaneal quantitative ultrasound and bone mineral density. Calcif Tissue Int. 2011; 90(2):128-36. DOI: 10.1007/s00223-011-9556-3. View

Kwok T, Khoo C, Leung J, Kwok A, Qin L, Woo J . Predictive values of calcaneal quantitative ultrasound and dual energy X ray absorptiometry for non-vertebral fracture in older men: results from the MrOS study (Hong Kong). Osteoporos Int. 2011; 23(3):1001-6. DOI: 10.1007/s00198-011-1634-x. View

Kanis J, McCloskey E, Johansson H, Cooper C, Rizzoli R, Reginster J . European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 2012; 24(1):23-57. PMC: 3587294. DOI: 10.1007/s00198-012-2074-y. View

10.

Turunen M, Prantner V, Jurvelin J, Kroger H, Isaksson H . Composition and microarchitecture of human trabecular bone change with age and differ between anatomical locations. Bone. 2013; 54(1):118-25. DOI: 10.1016/j.bone.2013.01.045. View

11.

Ackerman K, Pierce L, Guereca G, Slattery M, Lee H, Goldstein M . Hip structural analysis in adolescent and young adult oligoamenorrheic and eumenorrheic athletes and nonathletes. J Clin Endocrinol Metab. 2013; 98(4):1742-9. PMC: 3615200. DOI: 10.1210/jc.2013-1006. View

12.

Misra M, Katzman D, Clarke H, Snelgrove D, Brigham K, Miller K . Hip structural analysis in adolescent boys with anorexia nervosa and controls. J Clin Endocrinol Metab. 2013; 98(7):2952-8. PMC: 3701273. DOI: 10.1210/jc.2013-1457. View

13.

Chiba K, Burghardt A, Osaki M, Majumdar S . Heterogeneity of bone microstructure in the femoral head in patients with osteoporosis: an ex vivo HR-pQCT study. Bone. 2013; 56(1):139-46. PMC: 3740186. DOI: 10.1016/j.bone.2013.05.019. View

14.

Emaus N, Wilsgaard T, Ahmed L . Impacts of body mass index, physical activity, and smoking on femoral bone loss: the Tromsø study. J Bone Miner Res. 2014; 29(9):2080-9. DOI: 10.1002/jbmr.2232. View

15.

Lv H, Yang F, Li M, Su X, Yin P, Zhang L . A novel 3D-printed device for localization and extraction of trabeculae from human femoral heads: a comparison with traditional visual extraction. Osteoporos Int. 2015; 26(6):1791-9. DOI: 10.1007/s00198-015-3058-5. View

16.

Frost M, Blake G, Fogelman I . Can the WHO criteria for diagnosing osteoporosis be applied to calcaneal quantitative ultrasound?. Osteoporos Int. 2000; 11(4):321-30. DOI: 10.1007/s001980070121. View

17.

Jorgensen H, Warming L, Bjarnason N, Andersen P, Hassager C . How does quantitative ultrasound compare to dual X-ray absorptiometry at various skeletal sites in relation to the WHO diagnosis categories?. Clin Physiol. 2001; 21(1):51-9. DOI: 10.1046/j.1365-2281.2001.00298.x. View

18.

Eckstein F, Lochmuller E, Lill C, Kuhn V, Schneider E, Delling G . Bone strength at clinically relevant sites displays substantial heterogeneity and is best predicted from site-specific bone densitometry. J Bone Miner Res. 2002; 17(1):162-71. DOI: 10.1359/jbmr.2002.17.1.162. View

19.

Ikeda Y, Iki M, Morita A, Aihara H, Kagamimori S, Kagawa Y . Age-specific values and cutoff levels for the diagnosis of osteoporosis in quantitative ultrasound measurements at the calcaneus with SAHARA in healthy Japanese women: Japanese population-based osteoporosis (JPOS) study. Calcif Tissue Int. 2002; 71(1):1-9. DOI: 10.1007/s00223-001-2079-6. View

20.

Krieg M, Cornuz J, Ruffieux C, Sandini L, Buche D, Dambacher M . Comparison of three bone ultrasounds for the discrimination of subjects with and without osteoporotic fractures among 7562 elderly women. J Bone Miner Res. 2003; 18(7):1261-6. DOI: 10.1359/jbmr.2003.18.7.1261. View