Future Perspectives in Bladder Tissue Engineering

Overview

Journal Curr Bladder Dysfunct Rep

Publisher Springer

Date 2015 Dec 29

PMID 26709356

Citations 6

Authors

Bradley C Gill

Margot S Damaser

Christopher J Chermansky

Affiliations

Soon will be listed here.

Abstract

Substantial clinical need persists for improved autologous tissues to augment or replace the urinary bladder and research has begun to address this using tissue engineering techniques. The implantation of both tissue scaffolds which allow for native bladder tissue ingrowth and autologous bladder grafts created from in vitro cellularization of such scaffolds have been tested clinically; however, successful outcomes in both scenarios have been challenged by insufficient vascularity resulting from large graft sizes, which subsequently limits tissue ingrowth and leads to central graft ischemia. Consequently, recent research has focused on developing better methods to produce scaffolds with increased tissue ingrowth and vascularity. This review provides an update on bladder tissue engineering and outlines the challenges that remain to clinical implementation.

Citing Articles

Recent advances and future directions in urinary system tissue engineering.

Yuan J, Suo D, Li P, Zhao X, Wang H, Chen B Mater Today Bio. 2025; 31:101600.

PMID: 40066078 PMC: 11891153. DOI: 10.1016/j.mtbio.2025.101600.

Tissue Engineering in Pediatric Bladder Reconstruction-The Road to Success.

Horst M, Eberli D, Gobet R, Salemi S Front Pediatr. 2019; 7:91.

PMID: 30984717 PMC: 6449422. DOI: 10.3389/fped.2019.00091.

Engineering molecular imaging strategies for regenerative medicine.

Willadsen M, Chaise M, Yarovoy I, Zhang A, Parashurama N Bioeng Transl Med. 2018; 3(3):232-255.

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Folding artificial mucosa with cell-laden hydrogels guided by mechanics models.

Chan H, Zhao R, Parada G, Meng H, Leong K, Griffith L Proc Natl Acad Sci U S A. 2018; 115(29):7503-7508.

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Bladder biomechanics and the use of scaffolds for regenerative medicine in the urinary bladder.

Ajalloueian F, Lemon G, Hilborn J, Chronakis I, Fossum M Nat Rev Urol. 2018; 15(3):155-174.

PMID: 29434369 DOI: 10.1038/nrurol.2018.5.

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