Fluid Overload and Acute Kidney Injury: Cause or Consequence?

Overview

Journal Crit Care

Specialty Critical Care

Date 2015 Dec 29

PMID 26707872

Citations 37

Authors

Marlies Ostermann

Heleen M Oudemans-van Straaten

Lui G Forni

Affiliations

Soon will be listed here.

Abstract

There is increasing evidence that fluid overload and acute kidney injury (AKI) are associated but the exact cause-effect relationship remains unclear. Wang and colleagues analysed patients admitted to 30 intensive care units in China and found that fluid accumulation was independently associated with an increased risk of AKI and mortality. This commentary focuses on the close pathophysiological link between AKI and fluid overload and discusses the implications for clinical practice. It outlines some of the challenges, including the difficulty in diagnosing fluid overload reliably with current methods, and stresses the importance of personalised fluid therapy with physiological end-points to avoid the deleterious effects of fluid overload.

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