Pelvic MRI Findings in Relapsed Prostate Cancer After Radical Prostatectomy

Overview

Journal Radiat Oncol

Publisher Biomed Central

Specialties Oncology
Radiology

Date 2015 Dec 26

PMID 26704623

Citations 15

Authors

D Hernandez

D Salas

D Gimenez

P Buitrago

S Esquena

J Palou

P de la Torre

J Pernas

I Gich

G Gomez de Segura

J Craven-Bartle

G Sancho

Affiliations

Soon will be listed here.

Abstract

Purpose/objective: Little is known about the clinical impact of using multiparametric MRI to plan early salvage radiotherapy after radical prostatectomy. We aimed to evaluate the incidence and location of recurrence based on pelvic multiparametric MRI findings and to identify clinical variables predictive of positive imaging results.

Materials And Methods: We defined radiological criteria of local and lymph node malignancy and reviewed records and MRI studies of 70 patients with PSA recurrence after radical prostatectomy. We performed univariate and multivariate analysis to identify any association between clinical, pathological and treatment-related variables and imaging results.

Results: Multiparametric MRI was positive in 33/70 patients. We found local and lymph node recurrence in 27 patients and 7 patients, respectively, with a median PSA value of 0.38 ng/ml. We found no statistically significant differences between patients with positive and negative multiparametric MRI for any variable. Shorter PSADT was associated with positive lymph nodes (median PSADT: 5.12 vs 12.70 months; p: 0.017).

Conclusions: Nearly half the patients had visible disease in multiparametric MRI despite low PSA. Positive lymph nodes incidence should be considered when planning salvage radiotherapy, particularly in patients with a short PSADT.

Citing Articles

Imaging assessment of prostate cancer recurrence: advances in detection of local and systemic relapse.

Muglia V, Laschena L, Pecoraro M, de Lion Gouvea G, Colli L, Panebianco V Abdom Radiol (NY). 2024; 50(2):807-826.

PMID: 39254707 DOI: 10.1007/s00261-024-04412-7.

Diagnostic yield of multiparametric MRI for local recurrence at biochemical recurrence after radical prostatectomy.

Kim M, Hwang S, Ahn H, Lee H, Byun S, Hong S Prostate Int. 2022; 10(3):135-141.

PMID: 36225284 PMC: 9520418. DOI: 10.1016/j.prnil.2022.05.001.

Detecting and Locating the Site of Local Relapse Using F-PSMA-1007 Imaging After Primary Treatment of 135 Prostate Cancer Patients-Potential Impact on PSMA-Guided Radiation Therapy.

Koerber S, Kroener R, Dendl K, Kratochwil C, Fink C, Ristau J Mol Imaging Biol. 2022; 25(2):375-383.

PMID: 35999425 PMC: 10006015. DOI: 10.1007/s11307-022-01766-6.

Targeting Local Recurrence After Surgery With MRI Imaging for Prostate Cancer in the Setting of Salvage Radiation Therapy.

Renard-Penna R, Zhang-Yin J, Montagne S, Aupin L, Bruguiere E, Labidi M Front Oncol. 2022; 12:775387.

PMID: 35242702 PMC: 8887697. DOI: 10.3389/fonc.2022.775387.

Predictors of prostate bed recurrence on magnetic resonance imaging in patients with rising prostate-specific antigen after radical prostatectomy.

Nasser N, Chernyak V, Shankar V, Garg M, Bodner W, Kalnicki S Can Urol Assoc J. 2020; 15(1):E22-E28.

PMID: 32701441 PMC: 7769522. DOI: 10.5489/cuaj.6463.

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