Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified As Restriction Factors Antagonized by the Pathogenesis Factor

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2015 Dec 26

PMID 26703715

Citations 11

Authors

Oliver T Fackler

Affiliations

Soon will be listed here.

Abstract

The Nef protein is an accessory gene product encoded by human immunodeficiency virus types 1 and 2 (HIV-1/-2) and simian immunodeficiency virus (SIV) that boosts virus replication in the infected host and accelerates disease progression. Unlike the HIV-1 accessory proteins Vif, Vpr and Vpu, Nef was, until recently, not known to antagonize the antiviral activity of a host cell restriction factor. Two recent reports now describe the host cell proteins serine incorporator 3 and 5 (SERINC3 and SERINC5) as potent inhibitors of HIV-1 particle infectivity and demonstrate that Nef counteracts these effects. These findings establish SERINC3/5 as restrictions to HIV replication in human cells and define a novel activity for the HIV pathogenesis factor Nef.

Citing Articles

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Beyond Impairment of Virion Infectivity: New Activities of the Anti-HIV Host Cell Factor SERINC5.

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