Cardiac Regeneration: Epicardial Mediated Repair

Overview

Journal Proc Biol Sci

Specialty Biology

Date 2015 Dec 25

PMID 26702046

Citations 16

Authors

Teresa Kennedy-Lydon

Nadia Rosenthal

Affiliations

Soon will be listed here.

Abstract

The hearts of lower vertebrates such as fish and salamanders display scarless regeneration following injury, although this feature is lost in adult mammals. The remarkable capacity of the neonatal mammalian heart to regenerate suggests that the underlying machinery required for the regenerative process is evolutionarily retained. Recent studies highlight the epicardial covering of the heart as an important source of the signalling factors required for the repair process. The developing epicardium is also a major source of cardiac fibroblasts, smooth muscle, endothelial cells and stem cells. Here, we examine animal models that are capable of scarless regeneration, the role of the epicardium as a source of cells, signalling mechanisms implicated in the regenerative process and how these mechanisms influence cardiomyocyte proliferation. We also discuss recent advances in cardiac stem cell research and potential therapeutic targets arising from these studies.

Citing Articles

Pericardial Involvement in ST-Segment Elevation Myocardial Infarction as Detected by Cardiac MRI.

Massalha E, Brodov Y, Oren D, Fardman A, Natanzon S, Mazin I Front Cardiovasc Med. 2022; 9:752626.

PMID: 35282340 PMC: 8911035. DOI: 10.3389/fcvm.2022.752626.

Bisphosphonate of Zoledronate Has Antiapoptotic Effect on Hypoxia/Reoxygenation Injury in Human Embryonic Stem Cell-Derived Cardiomyocytes Through Trk Signaling Pathway.

Wang H, Zhao W, Xu L Cell Biochem Biophys. 2022; 80(2):435-442.

PMID: 35226248 DOI: 10.1007/s12013-021-01031-7.

Notch and Bmp signaling pathways act coordinately during the formation of the proepicardium.

Andres-Delgado L, Galardi-Castilla M, Munch J, Peralta M, Ernst A, Gonzalez-Rosa J Dev Dyn. 2020; 249(12):1455-1469.

PMID: 33103836 PMC: 7754311. DOI: 10.1002/dvdy.229.

Analysis of wt1a reporter line expression levels during proepicardium formation in the zebrafish.

Andres-Delgado L, Galardi-Castilla M, Mercader N, Santamaria L Histol Histopathol. 2020; 35(9):1035-1046.

PMID: 32633330 DOI: 10.14670/HH-18-238.

Applications of miRNAs in cardiac development, disease progression and regeneration.

Pang J, Phua Q, Soh B Stem Cell Res Ther. 2019; 10(1):336.

PMID: 31752983 PMC: 6868784. DOI: 10.1186/s13287-019-1451-2.

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