Monitoring Exposure to Polycyclic Aromatic Hydrocarbons in an Australian Population Using Pooled Urine Samples

Overview

Journal Environ Int

Specialties Environmental Health
Toxicology

Date 2015 Dec 25

PMID 26700419

Citations 9

Authors

Phong K Thai

Amy L Heffernan

Leisa-Maree L Toms

Zheng Li

Antonia M Calafat

Peter Hobson

Sara Broomhall

Jochen F Mueller

Affiliations

Soon will be listed here.

Abstract

Integrated exposure to polycyclic aromatic hydrocarbons (PAHs) can be assessed through monitoring of urinary mono-hydroxylated PAHs (OH-PAHs). The aim of this study was to provide the first assessment of exposure to PAHs in a large sample of the population in Queensland, Australia including exposure to infant (0-4years). De-identified urine specimens, obtained from a pathology laboratory, were stratified by age and sex, and pooled (n=24 pools of 100) and OH-PAHs were measured by gas chromatography-isotope dilution-tandem mass spectrometry. Geometric mean (GM) concentrations ranged from 30ng/L (4-hydroxyphenanthrene) to 9221ng/L (1-naphthol). GM of 1-hydroxypyrene, the most commonly used PAH exposure biomarker, was 142ng/L. The concentrations of OH-PAHs found in this study are consistent with those in developed countries and lower than those in developing countries. We observed no association between sex and OH-PAH concentrations. However, we observed lower urinary concentrations of all OH-PAHs in samples from infants (0-4years), children (5-14years) and the elderly (>60year old) compared with samples from other age groups (15-29, 30-44 and 45-59years) which may be attributed to age-dependent behaviour-specific exposure sources.

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