The Role of Insulin/IGF-1 Signaling in the Longevity of Model Invertebrates, C. Elegans and D. Melanogaster

Overview

Journal BMB Rep

Specialties Biochemistry
Molecular Biology

Date 2015 Dec 25

PMID 26698870

Citations 80

Authors

Ozlem Altintas

Sangsoon Park

Seung-Jae V Lee

Affiliations

Soon will be listed here.

Abstract

Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many organisms, ranging from simple invertebrates to mammals, including humans. Many seminal discoveries regarding the roles of IIS in aging and longevity have been made by using the roundworm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. In this review, we describe the mechanisms by which various IIS components regulate aging in C. elegans and D. melanogaster. We also cover systemic and tissue-specific effects of the IIS components on the regulation of lifespan. We further discuss IIS-mediated physiological processes other than aging and their effects on human disease models focusing on C. elegans studies. As both C. elegans and D. melanogaster have been essential for key findings regarding the effects of IIS on organismal aging in general, these invertebrate models will continue to serve as workhorses to help our understanding of mammalian aging. [BMB Reports 2016; 49(2): 81-92].

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References

Ewald C, Landis J, Abate J, Murphy C, Blackwell T . Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity. Nature. 2014; 519(7541):97-101. PMC: 4352135. DOI: 10.1038/nature14021. View

Fay D, Fluet A, Johnson C, Link C . In vivo aggregation of beta-amyloid peptide variants. J Neurochem. 1998; 71(4):1616-25. DOI: 10.1046/j.1471-4159.1998.71041616.x. View

Oeda T, Shimohama S, Kitagawa N, Kohno R, Imura T, Shibasaki H . Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans. Hum Mol Genet. 2001; 10(19):2013-23. DOI: 10.1093/hmg/10.19.2013. View

Jeong D, Artan M, Seo K, Lee S . Regulation of lifespan by chemosensory and thermosensory systems: findings in invertebrates and their implications in mammalian aging. Front Genet. 2012; 3:218. PMC: 3475297. DOI: 10.3389/fgene.2012.00218. View

Barsyte D, Lovejoy D, Lithgow G . Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans. FASEB J. 2001; 15(3):627-34. DOI: 10.1096/fj.99-0966com. View

Demontis F, Perrimon N . FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell. 2010; 143(5):813-25. PMC: 3066043. DOI: 10.1016/j.cell.2010.10.007. View

Tu M, Epstein D, Tatar M . The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico. Aging Cell. 2003; 1(1):75-80. DOI: 10.1046/j.1474-9728.2002.00010.x. View

Broughton S, Piper M, Ikeya T, Bass T, Jacobson J, Driege Y . Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc Natl Acad Sci U S A. 2005; 102(8):3105-10. PMC: 549445. DOI: 10.1073/pnas.0405775102. View

Douglas P, Baird N, Simic M, Uhlein S, McCormick M, Wolff S . Heterotypic Signals from Neural HSF-1 Separate Thermotolerance from Longevity. Cell Rep. 2015; 12(7):1196-1204. PMC: 4889220. DOI: 10.1016/j.celrep.2015.07.026. View

10.

Ogg S, Ruvkun G . The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol Cell. 1999; 2(6):887-93. DOI: 10.1016/s1097-2765(00)80303-2. View

11.

Bohni R, Riesgo-Escovar J, Oldham S, Brogiolo W, Stocker H, Andruss B . Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. Cell. 1999; 97(7):865-75. DOI: 10.1016/s0092-8674(00)80799-0. View

12.

Ermolaeva M, Schumacher B . Insights from the worm: the C. elegans model for innate immunity. Semin Immunol. 2014; 26(4):303-9. PMC: 4248339. DOI: 10.1016/j.smim.2014.04.005. View

13.

Gao X, Neufeld T, Pan D . Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways. Dev Biol. 2000; 221(2):404-18. DOI: 10.1006/dbio.2000.9680. View

14.

Haselton A, Sharmin E, Schrader J, Sah M, Poon P, Fridell Y . Partial ablation of adult Drosophila insulin-producing neurons modulates glucose homeostasis and extends life span without insulin resistance. Cell Cycle. 2010; 9(15):3063-71. PMC: 3230477. DOI: 10.4161/cc.9.15.12458. View

15.

Lin K, Dorman J, Rodan A, Kenyon C . daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science. 1997; 278(5341):1319-22. DOI: 10.1126/science.278.5341.1319. View

16.

Li J, Tewari M, Vidal M, Lee S . The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans. Dev Biol. 2006; 301(1):82-91. PMC: 1963419. DOI: 10.1016/j.ydbio.2006.10.013. View

17.

Brignull H, Moore F, Tang S, Morimoto R . Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model. J Neurosci. 2006; 26(29):7597-606. PMC: 6674286. DOI: 10.1523/JNEUROSCI.0990-06.2006. View

18.

Poltilove R, Jacobs A, Haft C, Xu P, Taylor S . Characterization of Drosophila insulin receptor substrate. J Biol Chem. 2000; 275(30):23346-54. DOI: 10.1074/jbc.M003579200. View

19.

Staab T, Griffen T, Corcoran C, Evgrafov O, Knowles J, Sieburth D . The conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegans. PLoS Genet. 2013; 9(3):e1003354. PMC: 3605294. DOI: 10.1371/journal.pgen.1003354. View

20.

Pasinelli P, Brown R . Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat Rev Neurosci. 2006; 7(9):710-23. DOI: 10.1038/nrn1971. View