A Simple Method to Simultaneously Detect and Identify Spikes from Raw Extracellular Recordings

Overview

Journal Front Neurosci

Date 2015 Dec 24

PMID 26696813

Citations 3

Authors

Panagiotis C Petrantonakis

Panayiota Poirazi

Affiliations

Soon will be listed here.

Abstract

The ability to track when and which neurons fire in the vicinity of an electrode, in an efficient and reliable manner can revolutionize the neuroscience field. The current bottleneck lies in spike sorting algorithms; existing methods for detecting and discriminating the activity of multiple neurons rely on inefficient, multi-step processing of extracellular recordings. In this work, we show that a single-step processing of raw (unfiltered) extracellular signals is sufficient for both the detection and identification of active neurons, thus greatly simplifying and optimizing the spike sorting approach. The efficiency and reliability of our method is demonstrated in both real and simulated data.

Citing Articles

Electrophysiological and Neurochemical Considerations of Distinct Neuronal Populations in the Rat Pedunculopontine Nucleus and Their Responsiveness Following 6-Hydroxydopamine Lesions.

Wang X, Geng X, Li M, Xie J, Chen D, Han H Front Neurosci. 2019; 13:1034.

PMID: 31616246 PMC: 6775246. DOI: 10.3389/fnins.2019.01034.

Spike sorting based on shape, phase, and distribution features, and K-TOPS clustering with validity and error indices.

Caro-Martin C, Delgado-Garcia J, Gruart A, Sanchez-Campusano R Sci Rep. 2018; 8(1):17796.

PMID: 30542106 PMC: 6290782. DOI: 10.1038/s41598-018-35491-4.

Contribution of action potentials to the extracellular field potential in the nucleus laminaris of barn owl.

Kuokkanen P, Ashida G, Kraemer A, McColgan T, Funabiki K, Wagner H J Neurophysiol. 2018; 119(4):1422-1436.

PMID: 29357463 PMC: 5966727. DOI: 10.1152/jn.00175.2017.

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