Laryngopharyngeal Reflux Disease in the Greek General Population, Prevalence and Risk Factors

Overview

Journal BMC Ear Nose Throat Disord

Publisher Biomed Central

Specialty Otorhinolaryngology

Date 2015 Dec 24

PMID 26696776

Citations 21

Authors

Nikolaos Spantideas

Eirini Drosou

Anastasia Bougea

Dimitrios Assimakopoulos

Affiliations

Soon will be listed here.

Abstract

Background: To assess the prevalence of laryngopharyngeal reflux (LPR) in the Greek general population and its risk factors.

Methods: Questionnaire based epidemiological, adult participants' survey. The Reflux Symptom Index (RSI) was used for the assessment of LPR prevalence. The RSI questionnaire was completed by 340 (183 male and 157 female) randomly selected subjects. Subjects with RSI score ≥13 were considered as LPR patients and those with RSI score <13 were considered as non LPR subjects.

Results: The prevalence of LPR in the general Greek population was found to be 18.8 % with no statistically significant difference between the two genders (p > 0.05). The age group of 50-64 years showed the higher prevalence rate. Tobacco smoking and alcohol consumption were found to be related with LPR. No reported concomitant disease or medication was found to be related with LPR.

Conclusions: LPR prevalence in the Greek general population was found to be 18.8 %. Tobacco smoking and alcohol consumption were found to be related with LPR.

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References

Belafsky P, Postma G, Koufman J . Validity and reliability of the reflux symptom index (RSI). J Voice. 2002; 16(2):274-7. DOI: 10.1016/s0892-1997(02)00097-8. View

Printza A, Kyrgidis A, Oikonomidou E, Triaridis S . Assessing laryngopharyngeal reflux symptoms with the Reflux Symptom Index: validation and prevalence in the Greek population. Otolaryngol Head Neck Surg. 2011; 145(6):974-80. DOI: 10.1177/0194599811425142. View

Ozturk O, Oz F, Karakullukcu B, Oghan F, Guclu E, Ada M . Hoarseness and laryngopharyngeal reflux: a cause and effect relationship or coincidence?. Eur Arch Otorhinolaryngol. 2006; 263(10):935-9. DOI: 10.1007/s00405-006-0097-8. View

Reulbach T, Belafsky P, Blalock P, Koufman J, Postma G . Occult laryngeal pathology in a community-based cohort. Otolaryngol Head Neck Surg. 2001; 124(4):448-50. DOI: 10.1067/mhn.2001.114256. View

Thompson W, Heaton K . Heartburn and globus in apparently healthy people. Can Med Assoc J. 1982; 126(1):46-8. PMC: 1862803. View

Reavis K, Morris C, Gopal D, Hunter J, Jobe B . Laryngopharyngeal reflux symptoms better predict the presence of esophageal adenocarcinoma than typical gastroesophageal reflux symptoms. Ann Surg. 2004; 239(6):849-56. PMC: 1356293. DOI: 10.1097/01.sla.0000128303.05898.ee. View

Vincent Jr D, Garrett J, Radionoff S, Reussner L, Stasney C . The proximal probe in esophageal pH monitoring: development of a normative database. J Voice. 2000; 14(2):247-54. DOI: 10.1016/s0892-1997(00)80033-8. View

Saruc M, Ayanoglu Aksoy E, Vardereli E, Karaaslan M, Cicek B, Ince U . Risk factors for laryngopharyngeal reflux. Eur Arch Otorhinolaryngol. 2011; 269(4):1189-94. DOI: 10.1007/s00405-011-1905-3. View

Koufman J . The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of.... Laryngoscope. 1991; 101(4 Pt 2 Suppl 53):1-78. DOI: 10.1002/lary.1991.101.s53.1. View

10.

Lai Y, Wang P, Lin J . Laryngopharyngeal reflux in patients with reflux esophagitis. World J Gastroenterol. 2008; 14(28):4523-8. PMC: 2731280. DOI: 10.3748/wjg.14.4523. View

11.

Gupta R, Sataloff R . Laryngopharyngeal reflux: current concepts and questions. Curr Opin Otolaryngol Head Neck Surg. 2009; 17(3):143-8. DOI: 10.1097/MOO.0b013e32832b2581. View

12.

Kamani T, Penney S, Mitra I, Pothula V . The prevalence of laryngopharyngeal reflux in the English population. Eur Arch Otorhinolaryngol. 2012; 269(10):2219-25. DOI: 10.1007/s00405-012-2028-1. View

13.

Feng G, Zhang L, Zhao L, Liu Y . [A pilot study on diagnosing laryngopharyngeal reflux disease by pH monitoring in laryngopharynx]. Zhonghua Yi Xue Za Zhi. 2008; 88(12):805-8. View

14.

Park S, Chun H, Keum B, Uhm C, Baek S, Jung K . An electron microscopic study--correlation of gastroesophageal reflux disease and laryngopharyngeal reflux. Laryngoscope. 2010; 120(7):1303-8. DOI: 10.1002/lary.20918. View

15.

Habermann W, Schmid C, Neumann K, Devaney T, Hammer H . Reflux symptom index and reflux finding score in otolaryngologic practice. J Voice. 2011; 26(3):e123-7. DOI: 10.1016/j.jvoice.2011.02.004. View

16.

Gasiorowska A, Poh C, Fass R . Gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS)--is it one disease or an overlap of two disorders?. Dig Dis Sci. 2008; 54(9):1829-34. DOI: 10.1007/s10620-008-0594-2. View

17.

Lowden M, McGlashan J, Steel A, Strugala V, Dettmar P . Prevalence of symptoms suggestive of extra-oesophageal reflux in a general practice population in the UK. Logoped Phoniatr Vocol. 2009; 34(1):32-5. DOI: 10.1080/14015430902735847. View

18.

Ruigomez A, Garcia Rodriguez L, Wallander M, Johansson S, Graffner H, Dent J . Natural history of gastro-oesophageal reflux disease diagnosed in general practice. Aliment Pharmacol Ther. 2004; 20(7):751-60. DOI: 10.1111/j.1365-2036.2004.02169.x. View

19.

Lin C, Wang Y, Wang K, Lien H, Liang M, Yen T . Association of heartburn and laryngopharyngeal symptoms with endoscopic reflux esophagitis, smoking, and drinking. Otolaryngol Head Neck Surg. 2009; 141(2):264-71. DOI: 10.1016/j.otohns.2009.05.017. View

20.

Cheung T, Lam P, Wei W, Wong W, Ng M, Gu Q . Quality of life in patients with laryngopharyngeal reflux. Digestion. 2009; 79(1):52-7. DOI: 10.1159/000205267. View