Proper Activation of MafA is Required for Optimal Differentiation and Maturation of Pancreatic β-cells

Overview

Journal Best Pract Res Clin Endocrinol Metab

Publisher Elsevier

Specialty Endocrinology

Date 2015 Dec 24

PMID 26696512

Citations 6

Authors

Ilham El Khattabi

Arun Sharma

Affiliations

Soon will be listed here.

Abstract

A key therapeutic approach for the treatment of Type 1 diabetes (T1D) is transplantation of functional islet β-cells. Despite recent advances in generating stem cell-derived glucose-responsive insulin(+) cells, their further maturation to fully functional adult β-cells still remains a daunting task. Conquering this hurdle will require a better understanding of the mechanisms driving maturation of embryonic insulin(+) cells into adult β-cells, and the implementation of that knowledge to improve current differentiation protocols. Here, we will review our current understanding of β-cell maturation, and discuss the contribution of key β-cell transcription factor MafA, to this process. The fundamental importance of MafA in regulating adult β-cell maturation and function indicates that enhancing MafA expression may improve the generation of definitive β-cells for transplantation. Additionally, we suggest that the temporal control of MafA induction at a specific stage of β-cell differentiation will be the next critical challenge for achieving optimum maturation of β-cells.

Citing Articles

Human pluripotent stem cell-derived β cells: Truly immature islet β cells for type 1 diabetes therapy?.

Jiang H, Jiang F World J Stem Cells. 2023; 15(4):182-195.

PMID: 37180999 PMC: 10173812. DOI: 10.4252/wjsc.v15.i4.182.

Role of the Transcription Factor MAFA in the Maintenance of Pancreatic β-Cells.

Nishimura W, Iwasa H, Tumurkhuu M Int J Mol Sci. 2022; 23(9).

PMID: 35562869 PMC: 9101179. DOI: 10.3390/ijms23094478.

Single Molecule-Based fliFISH Validates Radial and Heterogeneous Gene Expression Patterns in Pancreatic Islet β-Cells.

Li F, Hu D, Dieter C, Ansong C, Sussel L, Orr G Diabetes. 2021; 70(5):1117-1122.

PMID: 33685924 PMC: 8173798. DOI: 10.2337/db20-0802.

Insulin/Glucose-Responsive Cells Derived from Induced Pluripotent Stem Cells: Disease Modeling and Treatment of Diabetes.

Gheibi S, Singh T, da Cunha J, Fex M, Mulder H Cells. 2020; 9(11).

PMID: 33198288 PMC: 7696367. DOI: 10.3390/cells9112465.

Signaling Molecules Regulating Pancreatic Endocrine Development from Pluripotent Stem Cell Differentiation.

Huang H, Bader T, Jin S Int J Mol Sci. 2020; 21(16).

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