Prophylactic Drug Treatment of Migraine in Children and Adolescents: An Update

Overview

Journal Curr Pain Headache Rep

Date 2015 Dec 24

PMID 26695061

Citations 5

Authors

Janos Tajti

Delia Szok

Anett Csati

Laszlo Vecsei

Affiliations

Soon will be listed here.

Abstract

Migraine as a highly disabling pain condition influences the daily activities of those affected, including children and adolescents. The pathomechanism of migraine is not fully understood, and the different types of prophylactic antimigraine drugs that are applied are not specific for migraine. There is a need for preventive treatment in the event of frequent migraine attacks, an impairment of the quality of life, severe accompanying or aura symptoms, and the failure of acute drug treatment. The following pharmacological classes are recommended: antidepressants, antiepileptics, antihistamines, beta-adrenergic receptor blockers, and calcium ion channel antagonists, besides onabotulinum toxin A and nutraceuticals (butterbur). The most urgent goal as concerns pharmaceutical innovation is the development of pathomechanism-based antimigraine drugs and personalized therapy tailored to the children and adolescents.

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References

Evers S, Afra J, Frese A, Goadsby P, Linde M, May A . EFNS guideline on the drug treatment of migraine--revised report of an EFNS task force. Eur J Neurol. 2009; 16(9):968-81. DOI: 10.1111/j.1468-1331.2009.02748.x. View

Fallah R, Karbasi S, Shajari A, Fromandi M . The efficacy and safety of topiramate for prophylaxis of migraine in children. Iran J Child Neurol. 2014; 7(4):7-11. PMC: 3943045. View

Bernhard M, Bertsche A, Syrbe S, Weise S, Merkenschlager A . [Botulinum toxin injections for chronic migraine in adolescents - an early therapeutic option in the transition from neuropaediatrics to neurology]. Fortschr Neurol Psychiatr. 2014; 82(1):39-42. DOI: 10.1055/s-0033-1356312. View

Evers S . Treatment of migraine with prophylactic drugs. Expert Opin Pharmacother. 2008; 9(15):2565-73. DOI: 10.1517/14656566.9.15.2565. View

Dharmshaktu P, Tayal V, Kalra B . Efficacy of antidepressants as analgesics: a review. J Clin Pharmacol. 2011; 52(1):6-17. DOI: 10.1177/0091270010394852. View

Abbaskhanian A, Sadeghi H, Erfani A, Rezai M . Effective dose of topiramate in pediatric migraine prophylaxis. J Pediatr Neurosci. 2013; 7(3):171-4. PMC: 3611901. DOI: 10.4103/1817-1745.106470. View

Eidlitz-Markus T, Dlugatch Y, Haimi-Cohen Y, Goldberg-Stern H, Zeharia A . Nonpharmacologic treatment of migraine with low-dose propranolol or amitriptyline. Pediatr Neurol. 2012; 46(6):345-9. DOI: 10.1016/j.pediatrneurol.2012.03.017. View

Tuka B, Helyes Z, Markovics A, Bagoly T, Szolcsanyi J, Szabo N . Alterations in PACAP-38-like immunoreactivity in the plasma during ictal and interictal periods of migraine patients. Cephalalgia. 2013; 33(13):1085-95. DOI: 10.1177/0333102413483931. View

Lewis D, Ashwal S, Hershey A, Hirtz D, Yonker M, Silberstein S . Practice parameter: pharmacological treatment of migraine headache in children and adolescents: report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society. Neurology. 2004; 63(12):2215-24. DOI: 10.1212/01.wnl.0000147332.41993.90. View

10.

Orr S, Venkateswaran S . Nutraceuticals in the prophylaxis of pediatric migraine: Evidence-based review and recommendations. Cephalalgia. 2014; 34(8):568-83. DOI: 10.1177/0333102413519512. View

11.

Fritz N, Glogau S, Hoffmann J, Rademacher M, Elger C, Helmstaedter C . Efficacy and cognitive side effects of tiagabine and topiramate in patients with epilepsy. Epilepsy Behav. 2005; 6(3):373-81. DOI: 10.1016/j.yebeh.2005.01.002. View

12.

Tonekaboni S, Ghazavi A, Fayyazi A, Khajeh A, Taghdiri M, Abdollah Gorji F . Prophylaxis of childhood migraine: topiramate versus propranolol. Iran J Child Neurol. 2014; 7(1):9-14. PMC: 3943076. View

13.

Okuma H, Iijima K, Yasuda T, Tokuoka K, Kitagawa Y . Preventive effect of cyproheptadine hydrochloride in refractory patients with frequent migraine. Springerplus. 2013; 2:573. PMC: 3824712. DOI: 10.1186/2193-1801-2-573. View

14.

Wright C, Downing J, Mungall D, Khan O, Williams A, Fonkem E . Clinical pharmacology and pharmacokinetics of levetiracetam. Front Neurol. 2013; 4:192. PMC: 3850169. DOI: 10.3389/fneur.2013.00192. View

15.

Merikangas K . Contributions of epidemiology to our understanding of migraine. Headache. 2013; 53(2):230-46. DOI: 10.1111/head.12038. View

16.

Ernst M, OBrien H, Powers S . Cognitive-Behavioral Therapy: How Medical Providers Can Increase Patient and Family Openness and Access to Evidence-Based Multimodal Therapy for Pediatric Migraine. Headache. 2015; 55(10):1382-96. PMC: 4715506. DOI: 10.1111/head.12605. View

17.

Tajti J, Szok D, Tuka B, Csati A, Kuris A, Majlath Z . [Botulinum neurotoxin--a therapy in migraine]. Ideggyogy Sz. 2012; 65(3-4):77-82. View

18.

Sheridan D, Spiro D, Meckler G . Pediatric migraine: abortive management in the emergency department. Headache. 2014; 54(2):235-45. DOI: 10.1111/head.12253. View

19.

Pothmann R, Danesch U . Migraine prevention in children and adolescents: results of an open study with a special butterbur root extract. Headache. 2005; 45(3):196-203. DOI: 10.1111/j.1526-4610.2005.05044.x. View

20.

Deaton T, Mauro L . Topiramate for migraine prophylaxis in pediatric patients. Ann Pharmacother. 2014; 48(5):638-43. DOI: 10.1177/1060028014521128. View