Synthesis and Evaluation of Neuroprotective Selenoflavanones

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2015 Dec 23

PMID 26690420

Citations 4

Authors

Yong-Sung Choi

Dong-Myung Kim

Yoon-Jung Kim

Sai Yang

Kyung-Tae Lee

Jong Hoon Ryu

Jin-Hyun Jeong

Affiliations

Soon will be listed here.

Abstract

The physicochemical properties and antioxidant activity of a molecule could be improved by the substitution of an oxygen atom in a molecule with selenium. We synthesized selenoflavanones and flavanones to evaluate their neuroprotective effects. The selenoflavanones showed improved physicochemical properties, suggestive of the ability to pass through the blood-brain barrier (BBB). They showed in vitro antioxidant effects against hydrogen peroxide, and did not result in severe cytotoxicity. Moreover, infarction volumes in a transient ischemia mouse model were significantly reduced by the selenoflavanone treatments.

Citing Articles

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