A Review of the Cognitive Effects Observed in Humans Following Acute Supplementation with Flavonoids, and Their Associated Mechanisms of Action

Overview

Journal Nutrients

Date 2015 Dec 23

PMID 26690214

Citations 46

Authors

Lynne Bell

Daniel J Lamport

Laurie T Butler

Claire M Williams

Affiliations

Soon will be listed here.

Abstract

Flavonoids are polyphenolic compounds found in varying concentrations in many plant-based foods. Recent studies suggest that flavonoids can be beneficial to both cognitive and physiological health. Long term flavonoid supplementation over a period of weeks or months has been extensively investigated and reviewed, particularly with respect to cognitive ageing and neurodegenerative disease. Significantly less focus has been directed towards the short term effects of single doses of flavonoids on cognition. Here, we review 21 such studies with particular emphasis on the subclass and dose of flavonoids administered, the cognitive domains affected by flavonoid supplementation, and the effect size of the response. The emerging evidence suggests that flavonoids may be beneficial to attention, working memory, and psychomotor processing speed in a general population. Episodic memory effects are less well defined and may be restricted to child or older adult populations. The evidence also points towards a dose-dependent effect of flavonoids, but the physiological mechanisms of action remain unclear. Overall, there is encouraging evidence that flavonoid supplementation can benefit cognitive outcomes within an acute time frame of 0-6 h. But larger studies, combining cognitive and physiological measures, are needed to strengthen the evidence base.

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References

Clostre F . [Ginkgo biloba extract (EGb 761). State of knowledge in the dawn of the year 2000]. Ann Pharm Fr. 1999; 57 Suppl 1:1S8-88. View

Kennedy D, Scholey A . Glucose administration, heart rate and cognitive performance: effects of increasing mental effort. Psychopharmacology (Berl). 2000; 149(1):63-71. DOI: 10.1007/s002139900335. View

Rein D, Lotito S, HOLT R, Keen C, SCHMITZ H, Fraga C . Epicatechin in human plasma: in vivo determination and effect of chocolate consumption on plasma oxidation status. J Nutr. 2000; 130(8S Suppl):2109S-14S. DOI: 10.1093/jn/130.8.2109S. View

Wang J, Schramm D, HOLT R, Ensunsa J, Fraga C, SCHMITZ H . A dose-response effect from chocolate consumption on plasma epicatechin and oxidative damage. J Nutr. 2000; 130(8S Suppl):2115S-9S. DOI: 10.1093/jn/130.8.2115S. View

Kennedy D, Scholey A, Wesnes K . The dose-dependent cognitive effects of acute administration of Ginkgo biloba to healthy young volunteers. Psychopharmacology (Berl). 2000; 151(4):416-23. DOI: 10.1007/s002130000501. View

Graefe E, Wittig J, Mueller S, Riethling A, Uehleke B, Drewelow B . Pharmacokinetics and bioavailability of quercetin glycosides in humans. J Clin Pharmacol. 2001; 41(5):492-9. DOI: 10.1177/00912700122010366. View

Kennedy D, Scholey A, Wesnes K . Modulation of cognition and mood following administration of single doses of Ginkgo biloba, ginseng, and a ginkgo/ginseng combination to healthy young adults. Physiol Behav. 2002; 75(5):739-51. DOI: 10.1016/s0031-9384(02)00665-0. View

Holt R, Lazarus S, Sullards M, Zhu Q, Schramm D, Hammerstone J . Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa. Am J Clin Nutr. 2002; 76(4):798-804. DOI: 10.1093/ajcn/76.4.798. View

Ciani E, Guidi S, Bartesaghi R, Contestabile A . Nitric oxide regulates cGMP-dependent cAMP-responsive element binding protein phosphorylation and Bcl-2 expression in cerebellar neurons: implication for a survival role of nitric oxide. J Neurochem. 2002; 82(5):1282-9. DOI: 10.1046/j.1471-4159.2002.01080.x. View

10.

Nathan P, Ricketts E, Wesnes K, Mrazek L, Greville W, Stough C . The acute nootropic effects of Ginkgo biloba in healthy older human subjects: a preliminary investigation. Hum Psychopharmacol. 2002; 17(1):45-9. DOI: 10.1002/hup.353. View

11.

Beecher G . Overview of dietary flavonoids: nomenclature, occurrence and intake. J Nutr. 2003; 133(10):3248S-3254S. DOI: 10.1093/jn/133.10.3248S. View

12.

Stoclet J, Chataigneau T, Ndiaye M, Oak M, El Bedoui J, Chataigneau M . Vascular protection by dietary polyphenols. Eur J Pharmacol. 2004; 500(1-3):299-313. DOI: 10.1016/j.ejphar.2004.07.034. View

13.

Manach C, Williamson G, Morand C, Scalbert A, Remesy C . Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr. 2005; 81(1 Suppl):230S-242S. DOI: 10.1093/ajcn/81.1.230S. View

14.

Elsabagh S, Hartley D, Ali O, Williamson E, File S . Differential cognitive effects of Ginkgo biloba after acute and chronic treatment in healthy young volunteers. Psychopharmacology (Berl). 2005; 179(2):437-46. DOI: 10.1007/s00213-005-2206-6. View

15.

Chen J, Zacharek A, Zhang C, Jiang H, Li Y, Roberts C . Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in mice. J Neurosci. 2005; 25(9):2366-75. PMC: 2791344. DOI: 10.1523/JNEUROSCI.5071-04.2005. View

16.

Ruitenberg A, den Heijer T, Bakker S, Van Swieten J, Koudstaal P, Hofman A . Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study. Ann Neurol. 2005; 57(6):789-94. DOI: 10.1002/ana.20493. View

17.

Bramham C, Messaoudi E . BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog Neurobiol. 2005; 76(2):99-125. DOI: 10.1016/j.pneurobio.2005.06.003. View

18.

Cardenas A, Moro M, Hurtado O, Leza J, Lizasoain I . Dual role of nitric oxide in adult neurogenesis. Brain Res Brain Res Rev. 2005; 50(1):1-6. DOI: 10.1016/j.brainresrev.2005.03.006. View

19.

Schroeter H, Heiss C, Balzer J, Kleinbongard P, Keen C, Hollenberg N . (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci U S A. 2006; 103(4):1024-9. PMC: 1327732. DOI: 10.1073/pnas.0510168103. View

20.

Francis S, Head K, Morris P, MacDonald I . The effect of flavanol-rich cocoa on the fMRI response to a cognitive task in healthy young people. J Cardiovasc Pharmacol. 2006; 47 Suppl 2:S215-20. DOI: 10.1097/00005344-200606001-00018. View