The Clinical Impact of Accurate Cystine Calculi Characterization Using Dual-Energy Computed Tomography

Overview

Journal Case Rep Radiol

Publisher Wiley

Specialty Radiology

Date 2015 Dec 22

PMID 26688770

Citations 1

Authors

William E Haley

El-Sayed H Ibrahim

Mingliang Qu

Joseph G Cernigliaro

David S Goldfarb

Cynthia H McCollough

Affiliations

Soon will be listed here.

Abstract

Dual-energy computed tomography (DECT) has recently been suggested as the imaging modality of choice for kidney stones due to its ability to provide information on stone composition. Standard postprocessing of the dual-energy images accurately identifies uric acid stones, but not other types. Cystine stones can be identified from DECT images when analyzed with advanced postprocessing. This case report describes clinical implications of accurate diagnosis of cystine stones using DECT.

Citing Articles

Improved display and detection of small renal stones using photon-counting detector CT compared to conventional energy-integrating detector CT.

Esquivel A, Potretzke T, Ferrero A, Inoue A, Hoodeshenans S, Mileto A Abdom Radiol (NY). 2025; .

PMID: 39865183 DOI: 10.1007/s00261-024-04781-z.

Detection and Characterization of Renal Stones by Using Photon-Counting-based CT.

Marcus R, Fletcher J, Ferrero A, Leng S, Halaweish A, Gutjahr R Radiology. 2018; 289(2):436-442.

PMID: 30084728 PMC: 6204218. DOI: 10.1148/radiol.2018180126.

References

Hartman R, Kawashima A, Takahashi N, Silva A, Vrtiska T, Leng S . Applications of dual-energy CT in urologic imaging: an update. Radiol Clin North Am. 2012; 50(2):191-205, v. DOI: 10.1016/j.rcl.2012.02.007. View

Sumorok N, Goldfarb D . Update on cystinuria. Curr Opin Nephrol Hypertens. 2013; 22(4):427-31. PMC: 4514483. DOI: 10.1097/MNH.0b013e3283621c5d. View

Lambert E, Asplin J, Herrell S, Miller N . Analysis of 24-hour urine parameters as it relates to age of onset of cystine stone formation. J Endourol. 2010; 24(7):1179-82. DOI: 10.1089/end.2010.0133. View

Thomas C, Heuschmid M, Schilling D, Ketelsen D, Tsiflikas I, Stenzl A . Urinary calculi composed of uric acid, cystine, and mineral salts: differentiation with dual-energy CT at a radiation dose comparable to that of intravenous pyelography. Radiology. 2010; 257(2):402-9. DOI: 10.1148/radiol.10100526. View

Edvardsson V, Goldfarb D, Lieske J, Beara-Lasic L, Anglani F, Milliner D . Hereditary causes of kidney stones and chronic kidney disease. Pediatr Nephrol. 2013; 28(10):1923-42. PMC: 4138059. DOI: 10.1007/s00467-012-2329-z. View

Hidas G, Eliahou R, Duvdevani M, Coulon P, Lemaitre L, Gofrit O . Determination of renal stone composition with dual-energy CT: in vivo analysis and comparison with x-ray diffraction. Radiology. 2010; 257(2):394-401. DOI: 10.1148/radiol.10100249. View

Primak A, Fletcher J, Vrtiska T, Dzyubak O, Lieske J, Jackson M . Noninvasive differentiation of uric acid versus non-uric acid kidney stones using dual-energy CT. Acad Radiol. 2007; 14(12):1441-7. PMC: 2743375. DOI: 10.1016/j.acra.2007.09.016. View

Ferrandino M, Pierre S, Simmons W, Paulson E, Albala D, Preminger G . Dual-energy computed tomography with advanced postimage acquisition data processing: improved determination of urinary stone composition. J Endourol. 2010; 24(3):347-54. DOI: 10.1089/end.2009.0193. View

Assimos D, Leslie S, Ng C, Streem S, Hart L . The impact of cystinuria on renal function. J Urol. 2002; 168(1):27-30. View

10.

Goldfarb D, Coe F, Asplin J . Urinary cystine excretion and capacity in patients with cystinuria. Kidney Int. 2006; 69(6):1041-7. DOI: 10.1038/sj.ki.5000104. View

11.

Primak A, Giraldo J, Eusemann C, Schmidt B, Kantor B, Fletcher J . Dual-source dual-energy CT with additional tin filtration: Dose and image quality evaluation in phantoms and in vivo. AJR Am J Roentgenol. 2010; 195(5):1164-74. PMC: 2963033. DOI: 10.2214/AJR.09.3956. View

12.

Chillaron J, Font-Llitjos M, Fort J, Zorzano A, Goldfarb D, Nunes V . Pathophysiology and treatment of cystinuria. Nat Rev Nephrol. 2010; 6(7):424-34. DOI: 10.1038/nrneph.2010.69. View

13.

Hendee W, OConnor M . Radiation risks of medical imaging: separating fact from fantasy. Radiology. 2012; 264(2):312-21. DOI: 10.1148/radiol.12112678. View

14.

McCollough C, Bushberg J, Fletcher J, Eckel L . Answers to Common Questions About the Use and Safety of CT Scans. Mayo Clin Proc. 2015; 90(10):1380-92. DOI: 10.1016/j.mayocp.2015.07.011. View