Developmental Competence of Oocytes Grown in Vitro: Has It Peaked Already?

Overview

Journal J Reprod Dev

Specialties Biology
Reproductive Medicine

Date 2015 Dec 22

PMID 26685717

Citations 11

Authors

Kanako Morohaku

Yuji Hirao

Yayoi Obata

Affiliations

Soon will be listed here.

Abstract

In vitro growth of immature oocytes provides opportunities to increase gametic resources and to understand the mechanisms underlying oocyte development. Many studies on the in vitro growth of oocytes have been reported thus far; however, only a few cases have been reported, which demonstrated that oocytes can support full-term development after in vitro fertilization. Our research group recently found that culture of mouse neonatal primordial follicles increased the birthrate; however, the establishment of an in vitro system that can completely mimic follicle or oocyte growth in vivo and control oogenesis remains an ongoing challenge.

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