Polycatechol Nanoparticle MRI Contrast Agents

Overview

Journal Small

Date 2015 Dec 19

PMID 26681255

Citations 7

Authors

Yiwen Li

Yuran Huang

Zhao Wang

Fabio Carniato

Yijun Xie

Joseph P Patterson

Matthew P Thompson

Christopher M Andolina

Treffly B Ditri

Jill E Millstone

Joshua S Figueroa

Jeffrey D Rinehart

Miriam Scadeng

Mauro Botta

Nathan C Gianneschi

Affiliations

Soon will be listed here.

Abstract

Amphiphilic triblock copolymers containing Fe(III) -catecholate complexes formulated as spherical- or cylindrical-shaped micellar nanoparticles (SMN and CMN, respectively) are described as new T1-weighted agents with high relaxivity, low cytotoxicity, and long-term stability in biological fluids. Relaxivities of both SMN and CMN exceed those of established gadolinium chelates across a wide range of magnetic field strengths. Interestingly, shape-dependent behavior is observed in terms of the particles' interactions with HeLa cells, with CMN exhibiting enhanced uptake and contrast via magnetic resonance imaging (MRI) compared with SMN. These results suggest that control over soft nanoparticle shape will provide an avenue for optimization of particle-based contrast agents as biodiagnostics. The polycatechol nanoparticles are proposed as suitable for preclinical investigations into their viability as gadolinium-free, safe, and effective imaging agents for MRI contrast enhancement.

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