Cellular Peptidyl-prolyl Cis/trans Isomerase Pin1 Facilitates Replication of Feline Coronavirus

Overview

Journal Antiviral Res

Publisher Elsevier

Date 2015 Dec 18

PMID 26675666

Citations 9

Authors

Yoshikazu Tanaka

Arisa Amano

Masateru Morisaki

Yuka Sato

Takashi Sasaki

Affiliations

Soon will be listed here.

Abstract

Although feline coronavirus (FCoV) causes feline infectious peritonitis (FIP), which is a fatal infectious disease, there are no effective therapeutic medicines or vaccines. Previously, in vitro studies have shown that cyclosporin (CsA) and FK506 inhibit virus replication in diverse coronaviruses. CsA and FK506 are targets of clinically relevant immunosuppressive drugs and bind to cellular cyclophilins (Cyps) or FK506 binding proteins (FKBPs), respectively. Both Cyp and FKBP have peptidyl-prolyl cis-trans isomerase (PPIase) activity. However, protein interacting with NIMA (Pin1), a member of the parvulin subfamily of PPIases that differs from Cyps and FKBPs, is essential for various signaling pathways. Here we demonstrated that genetic silencing or knockout of Pin1 resulted in decreased FCoV replication in vitro. Dipentamethylene thiuram monosulfide, a specific inhibitor of Pin1, inhibited FCoV replication. These data indicate that Pin1 modulates FCoV propagation.

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References

Lu K, Hanes S, Hunter T . A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature. 1996; 380(6574):544-7. DOI: 10.1038/380544a0. View

Carbajo-Lozoya J, Ma-Lauer Y, Malesevic M, Theuerkorn M, Kahlert V, Prell E . Human coronavirus NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine A-derivatives including Alisporivir. Virus Res. 2014; 184:44-53. PMC: 7114444. DOI: 10.1016/j.virusres.2014.02.010. View

Tanaka Y, Sato Y, Osawa S, Inoue M, Tanaka S, Sasaki T . Suppression of feline coronavirus replication in vitro by cyclosporin A. Vet Res. 2012; 43:41. PMC: 3403912. DOI: 10.1186/1297-9716-43-41. View

Wu C, Chen P, Yeh S . Nucleocapsid phosphorylation and RNA helicase DDX1 recruitment enables coronavirus transition from discontinuous to continuous transcription. Cell Host Microbe. 2014; 16(4):462-72. PMC: 7104987. DOI: 10.1016/j.chom.2014.09.009. View

Lu K, Zhou X . The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease. Nat Rev Mol Cell Biol. 2007; 8(11):904-16. DOI: 10.1038/nrm2261. View

Wulf G, Finn G, Suizu F, Lu K . Phosphorylation-specific prolyl isomerization: is there an underlying theme?. Nat Cell Biol. 2005; 7(5):435-41. DOI: 10.1038/ncb0505-435. View

Tatara Y, Lin Y, Bamba Y, Mori T, Uchida T . Dipentamethylene thiuram monosulfide is a novel inhibitor of Pin1. Biochem Biophys Res Commun. 2009; 384(3):394-8. DOI: 10.1016/j.bbrc.2009.04.144. View

Zuniga S, Cruz J, Sola I, Mateos-Gomez P, Palacio L, Enjuanes L . Coronavirus nucleocapsid protein facilitates template switching and is required for efficient transcription. J Virol. 2009; 84(4):2169-75. PMC: 2812394. DOI: 10.1128/JVI.02011-09. View

Yaffe M, Schutkowski M, Shen M, Zhou X, Stukenberg P, Rahfeld J . Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science. 1998; 278(5345):1957-60. DOI: 10.1126/science.278.5345.1957. View

10.

Zuniga S, Sola I, Moreno J, Sabella P, Plana-Duran J, Enjuanes L . Coronavirus nucleocapsid protein is an RNA chaperone. Virology. 2006; 357(2):215-27. PMC: 7111943. DOI: 10.1016/j.virol.2006.07.046. View

11.

Lim Y, Tran H, Park S, Yim S, Hwang S . Peptidyl-prolyl isomerase Pin1 is a cellular factor required for hepatitis C virus propagation. J Virol. 2011; 85(17):8777-88. PMC: 3165832. DOI: 10.1128/JVI.02533-10. View

12.

Vogels M, van Balkom B, Kaloyanova D, Batenburg J, Heck A, Helms J . Identification of host factors involved in coronavirus replication by quantitative proteomics analysis. Proteomics. 2010; 11(1):64-80. PMC: 7167679. DOI: 10.1002/pmic.201000309. View

13.

Iampietro M, Morissette G, Gravel A, Flamand L . Inhibition of interleukin-2 gene expression by human herpesvirus 6B U54 tegument protein. J Virol. 2014; 88(21):12452-63. PMC: 4248915. DOI: 10.1128/JVI.02030-14. View

14.

Wu C, Yeh S, Tsay Y, Shieh Y, Kao C, Chen Y . Glycogen synthase kinase-3 regulates the phosphorylation of severe acute respiratory syndrome coronavirus nucleocapsid protein and viral replication. J Biol Chem. 2008; 284(8):5229-39. PMC: 8011290. DOI: 10.1074/jbc.M805747200. View

15.

Walev I, Weise K, Falke D . Differentiation of herpes simplex virus-induced fusion from without and fusion from within by cyclosporin A and compound 48/80. J Gen Virol. 1991; 72 ( Pt 6):1377-82. DOI: 10.1099/0022-1317-72-6-1377. View

16.

Billich A, Hammerschmid F, Peichl P, Wenger R, Zenke G, Quesniaux V . Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein-cyclophilin A interactions. J Virol. 1995; 69(4):2451-61. PMC: 188920. DOI: 10.1128/JVI.69.4.2451-2461.1995. View

17.

Xu L, Khadijah S, Fang S, Wang L, Tay F, Liu D . The cellular RNA helicase DDX1 interacts with coronavirus nonstructural protein 14 and enhances viral replication. J Virol. 2010; 84(17):8571-83. PMC: 2918985. DOI: 10.1128/JVI.00392-10. View

18.

Lu P, Zhou X, Liou Y, Noel J, Lu K . Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function. J Biol Chem. 2001; 277(4):2381-4. DOI: 10.1074/jbc.C100228200. View

19.

Pedersen N . An update on feline infectious peritonitis: diagnostics and therapeutics. Vet J. 2014; 201(2):133-41. PMC: 7110619. DOI: 10.1016/j.tvjl.2014.04.016. View

20.

Lu K, Hunter T . Evidence for a NIMA-like mitotic pathway in vertebrate cells. Cell. 1995; 81(3):413-24. DOI: 10.1016/0092-8674(95)90394-1. View