Nutrition-dependent Control of Insect Development by Insulin-like Peptides

Overview

Journal Curr Opin Insect Sci

Publisher Elsevier

Specialty Biology

Date 2015 Dec 15

PMID 26664828

Citations 31

Authors

Naoki Okamoto

Naoki Yamanaka

Affiliations

Soon will be listed here.

Abstract

In metazoans, members of the insulin-like peptide (ILP) family play a role in multiple physiological functions in response to the nutritional status. ILPs have been identified and characterized in a wide variety of insect species. Insect ILPs that are mainly produced by several pairs of medial neurosecretory cells in the brain circulate in the hemolymph and act systemically on target tissues. Physiological and biochemical studies in Lepidoptera and genetic studies in the fruit fly have greatly expanded our knowledge of the physiological functions of ILPs. Here, we outline the recent progress of the structural classification of insect ILPs and overview recent studies that have elucidated the physiological functions of insect ILPs involved in nutrient-dependent growth during development.

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