Effect of a Phospho-oligosaccharidic Putative Insulin Messenger on Insulin Release in Rats

Overview

Journal Diabetologia

Specialty Endocrinology

Date 1989 May 1

PMID 2666215

Citations 1

Authors

W J Malaisse

A Albor

F Blachier

I Valverde

A Sener

J M Mato

Affiliations

Soon will be listed here.

Abstract

The phospho-oligosaccharide extracted from rat liver and supposed to act as the insulin second messenger inhibits glucose-stimulated insulin release. In the present study, this phospho-oligosaccharide was found not to affect D-[U-14C]glucose oxidation and 45Ca net uptake, but to inhibit insulin release evoked by either D-glucose or 2-ketoisocaproate in isolated rat islets. The relative extent of the latter inhibition was unaffected by either the concentration of D-glucose or the presence of dibutyryl-cyclic AMP, forskolin or glucagon in the incubation medium. At variance with the inhibitory effect of clonidine, that of the phospho-oligosaccharide was resistant to both blockade of alpha 2-adrenergic receptors or pre-treatment with the toxin of Bordetella pertussis. It is speculated, therefore, that such a phospho-oligosaccharide might interfere with a distal event in the insulin secretory sequence.

Citing Articles

The role of glycosyl-phosphoinositides in hormone action.

Saltiel A J Bioenerg Biomembr. 1991; 23(1):29-41.

PMID: 1849135 DOI: 10.1007/BF00768837.

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