Nanoscale Optomechanical Actuators for Controlling Mechanotransduction in Living Cells

Overview

Journal Nat Methods

Specialties Biomedical Engineering
Pathology

Date 2015 Dec 15

PMID 26657558

Citations 57

Authors

Zheng Liu

Yang Liu

Yuan Chang

Hamid Reza Seyf

Asegun Henry

Alexa L Mattheyses

Kevin Yehl

Yun Zhang

Zhuangqun Huang

Khalid Salaita

Affiliations

Soon will be listed here.

Abstract

To control receptor tension optically at the cell surface, we developed an approach involving optomechanical actuator nanoparticles that are controlled with near-infrared light. Illumination leads to particle collapse, delivering piconewton forces to specific cell surface receptors with high spatial and temporal resolution. We demonstrate optomechanical actuation by controlling integrin-based focal adhesion formation, cell protrusion and migration, and T cell receptor activation.

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