Effect of Zhuang Jing Decoction on Learning and Memory Ability in Aging Rats

Overview

Journal Rejuvenation Res

Specialties Geriatrics
Physiology

Date 2015 Dec 10

PMID 26649780

Citations 5

Authors

Hao-Bin Cai

Guang-Liang Wu

Cen-Han Huang

Zhong-Shi Huang

Yun-Bo Chen

Qi Wang

Affiliations

Soon will be listed here.

Abstract

With the average life span of humans on the rise, aging in the world has drawn considerable attentions. The monoamine neurotransmitters and neurotrophic factors in brain areas are involved in learning and memory processes and are an essential part of normal synaptic neurotransmission and plasticity. In the present study, the effect of Zhuang Jing Decoction (ZJD) on the learning and memory ability in aging rats was examined in vivo using Morris water maze. Furthermore, the levels of monoamine neurotransmitters and neurotrophic factors in brain were detected by high-performance liquid chromatography with a fluorescence detector and enzyme-linked immunosorbent assay, respectively. These data showed that oral administration with ZJD at the dose of 30 g·kg(-1) exerted an improved effect on learning and memory ability in aging rats. The results revealed that ZJD could effectively adjust the monoamine neurotransmitters and neurotrophic factors, restore the balance of the level of monoamine neurotransmitters and neurotrophic factors in brain, and finally attenuate the degeneration of learning and memory ability. These findings suggested that ZJD might be a potential agent as cognitive-enhancing drug in improving learning and memory ability. It may exert through regulating the levels of monoamine neurotransmitters and neurotrophic factors in brain, which demonstrated that ZJD had certain antiaging effects.

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References

Yan J, Liu M, Hu Y, Yu B, Zhang G, Liu P . [Effect and mechanism of dingzhixiao wan on scopolamine-induced learning-memory impairment in mice]. Zhongguo Zhong Yao Za Zhi. 2013; 37(21):3293-6. View

Petralia R, Mattson M, Yao P . Communication breakdown: the impact of ageing on synapse structure. Ageing Res Rev. 2014; 14:31-42. PMC: 4094371. DOI: 10.1016/j.arr.2014.01.003. View

Grillo F, Song S, Teles-Grilo Ruivo L, Huang L, Gao G, Knott G . Increased axonal bouton dynamics in the aging mouse cortex. Proc Natl Acad Sci U S A. 2013; 110(16):E1514-23. PMC: 3631669. DOI: 10.1073/pnas.1218731110. View

Fischer W, Sirevaag A, Wiegand S, Lindsay R, Bjorklund A . Reversal of spatial memory impairments in aged rats by nerve growth factor and neurotrophins 3 and 4/5 but not by brain-derived neurotrophic factor. Proc Natl Acad Sci U S A. 1994; 91(18):8607-11. PMC: 44655. DOI: 10.1073/pnas.91.18.8607. View

Diogenes M, Costenla A, Lopes L, Jeronimo-Santos A, Sousa V, Fontinha B . Enhancement of LTP in aged rats is dependent on endogenous BDNF. Neuropsychopharmacology. 2011; 36(9):1823-36. PMC: 3154100. DOI: 10.1038/npp.2011.64. View

Niewiadomska G, Mietelska-Porowska A, Mazurkiewicz M . The cholinergic system, nerve growth factor and the cytoskeleton. Behav Brain Res. 2010; 221(2):515-26. DOI: 10.1016/j.bbr.2010.02.024. View

Harley C . Norepinephrine and dopamine as learning signals. Neural Plast. 2005; 11(3-4):191-204. PMC: 2567044. DOI: 10.1155/np.2004.191. View

McEwen B . Sex, stress and the hippocampus: allostasis, allostatic load and the aging process. Neurobiol Aging. 2002; 23(5):921-39. DOI: 10.1016/s0197-4580(02)00027-1. View

Weinstein G, Beiser A, Choi S, Preis S, Chen T, Vorgas D . Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study. JAMA Neurol. 2013; 71(1):55-61. PMC: 4056186. DOI: 10.1001/jamaneurol.2013.4781. View

10.

Li L, Wei H, Zhang L, Chu J, Zhao L . [Modern biological basis of Chinese medical theory that "kidney nourishes marrow and brain is sea of marrow"]. Zhongguo Zhong Yao Za Zhi. 2006; 31(17):1397-400, 1417. View

11.

Liu H, Zhang J, Zheng P, Zhang Y . Altered expression of MAP-2, GAP-43, and synaptophysin in the hippocampus of rats with chronic cerebral hypoperfusion correlates with cognitive impairment. Brain Res Mol Brain Res. 2005; 139(1):169-77. DOI: 10.1016/j.molbrainres.2005.05.014. View

12.

Gupta R, Gupta L . Improvement in long term and visuo-spatial memory following chronic pioglitazone in mouse model of Alzheimer's disease. Pharmacol Biochem Behav. 2012; 102(2):184-90. DOI: 10.1016/j.pbb.2012.03.028. View

13.

Zhang X, Xing Y, Gong L, Li H, Wu Z, Li Y . Effects of ginsenoside Rg1 or 17β-estradiol on a cognitively impaired, ovariectomized rat model of Alzheimer's disease. Neuroscience. 2012; 220:191-200. DOI: 10.1016/j.neuroscience.2012.06.027. View

14.

Nazarali A, Reynolds G . Monoamine neurotransmitters and their metabolites in brain regions in Alzheimer's disease: a postmortem study. Cell Mol Neurobiol. 1992; 12(6):581-7. PMC: 11567239. DOI: 10.1007/BF00711237. View

15.

Lan Z, Liu J, Chen L, Fu Q, Luo J, Qu R . Danggui-Shaoyao-San ameliorates cognition deficits and attenuates oxidative stress-related neuronal apoptosis in d-galactose-induced senescent mice. J Ethnopharmacol. 2012; 141(1):386-95. DOI: 10.1016/j.jep.2012.02.050. View

16.

Hou X, Zhang L, Yang C, Rong C, He W, Zhang C . Alleviating effects of Bushen-Yizhi formula on ibotenic acid-induced cholinergic impairments in rat. Rejuvenation Res. 2014; 18(2):111-27. PMC: 4403018. DOI: 10.1089/rej.2014.1603. View

17.

Meneses A, Liy-Salmeron G . Serotonin and emotion, learning and memory. Rev Neurosci. 2012; 23(5-6):543-53. DOI: 10.1515/revneuro-2012-0060. View

18.

Oliveira L, Graeff F, Pereira S, Oliveira-Silva I, Franco G, Ribeiro A . Correlations among central serotonergic parameters and age-related emotional and cognitive changes assessed through the elevated T-maze and the Morris water maze. Age (Dordr). 2010; 32(2):187-96. PMC: 2861747. DOI: 10.1007/s11357-009-9123-2. View

19.

Niewiadomska G, Komorowski S, Baksalerska-Pazera M . Amelioration of cholinergic neurons dysfunction in aged rats depends on the continuous supply of NGF. Neurobiol Aging. 2002; 23(4):601-13. DOI: 10.1016/s0197-4580(01)00345-1. View

20.

Zhou L, Hou Y, Yang Q, Du X, Li M, Yuan M . Tetrahydroxystilbene glucoside improves the learning and memory of amyloid-β(₁₋₄₂)-injected rats and may be connected to synaptic changes in the hippocampus. Can J Physiol Pharmacol. 2012; 90(11):1446-55. DOI: 10.1139/y2012-121. View