Association Analysis of DISC1 Gene Polymorphisms with Attention-Deficit Hyperactivity Disorder in Iranian Population

Overview

Journal Pak J Med Sci

Specialty General Medicine

Date 2015 Dec 10

PMID 26649006

Citations 1

Authors

Matin Kayyal

Abolfazl Movafagh

Mehrdad Hashemi

Arezou Sayad

Babak Emamalizadeh

Khashayar Pouriran

Mohammadmoien Kayyal

Mohammad Reza Eslami Amirabadi

Mahdi Zamani

Hossein Darvish

Affiliations

Soon will be listed here.

Abstract

Background & Objectives: Attention deficit hyperactivity disorder (ADHD) is a common heritable psychiatric disorder with a worldwide prevalence of 5%. The etiology of ADHD is still incompletely understood, but several studies, consistently indicate the strong role of genetic factors on this disorder. The aim of this study was to determine the effect of three SNPs rs11122319, rs11122330 and rs6675281 in the etiology of ADHD in an Iranian children.

Methods: In this research work, for the first time, we investigated the association of three SNPs (rs11122330, rs6675281 and rs11122319) in the DISC1 gene with ADHD in Iranian population. Two hundred fourthy subjects composed of 120 patients and 120 healthy controls were included and tetra-primer ARMS PCR technique was used for genotyping all selected SNPs.

Results: We found differences in genotype and allele distributions of rs 6675281 polymorphism between our patients and controls. The A, T and A alleles were the more frequent alleles in rs11122319, rs6675281 and rs11122330 polymorphisms in both case and control groups respectively. The TT genotype was more frequent in control group compared to patients. (P value = 0.008, OR= 1.5837, 95% CI= 1.1012 to 2.2776).

Conclusion: Our findings strengthens the role of DISC1 gene as a susceptibility locus for ADHD and indicate that rs6675281 polymorphism is a susceptibility factor for ADHD for the first time in children reported in an Iranian population in this part of the world.

Citing Articles

Common and specific genes and peripheral biomarkers in children and adults with attention-deficit/hyperactivity disorder.

Bonvicini C, Faraone S, Scassellati C World J Biol Psychiatry. 2017; 19(2):80-100.

PMID: 28097908 PMC: 5568996. DOI: 10.1080/15622975.2017.1282175.

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