A Mild Hydration of Nitriles Catalysed by Copper(ii) Acetate

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2015 Dec 10

PMID 26645321

Citations 7

Authors

Patricia Marce

James Lynch

A John Blacker

Jonathan M J Williams

Affiliations

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Abstract

A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.

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