The Role of Central and Enteric Nervous Systems in the Control of the Retrograde Giant Contraction

Overview

Journal J Neurogastroenterol Motil

Date 2015 Dec 10

PMID 26645249

Citations 5

Authors

Ivan M Lang

Affiliations

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Abstract

Background/aims: The role of the enteric (ENS) and central (CNS) nervous systems in the control of the retrograde giant contraction (RGC) associated with vomiting is unknown.

Methods: The effects of myotomy or mesenteric nerve transection (MNT) on apomorphine-induced emesis were investigated in 18 chronically instrumented dogs.

Results: Neither surgery affected the RGC orad of the surgical site or the velocity of the RGC over the entire small intestine. Myotomy blocked the RGC for 17 ± 5 cm aborad of the myotomy, and the velocity of the RGC from 100 to 70 cm from the pylorus slowed (18.1 ± 3.0 to 9.0 ± 0.8 cm/sec) such that the RGC orad and aborad of the myotomy occurred simultaneously. After MNT, the RGC was unchanged up to 66 ± 6 cm from the pylorus, and the sequence of the RGC across the denervated intestine was unaltered. The velocity of the RGC from 100 to 70 cm from the pylorus increased from 12.8 ± 1.6 to 196 ± 116 cm/sec. After myotomy or MNT, the percent occurrence and magnitude of the RGC across the intestine 100 to 70 cm from the pylorus decreased.

Conclusions: The CNS activates the RGC 10 to 20 cm aborad of its innervation of the intestine and controls the RGC sequence. On the other hand, the ENS plays a role in initiation and generation of the RGC.

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References

Lang I, Sarna S, Dodds W . Pharyngeal, esophageal, and proximal gastric responses associated with vomiting. Am J Physiol. 1993; 265(5 Pt 1):G963-72. DOI: 10.1152/ajpgi.1993.265.5.G963. View

Berthoud H, Carlson N, Powley T . Topography of efferent vagal innervation of the rat gastrointestinal tract. Am J Physiol. 1991; 260(1 Pt 2):R200-7. DOI: 10.1152/ajpregu.1991.260.1.R200. View

Frantzides C, Sarna S, Matsumoto T, Lang I, Condon R . An intrinsic neural pathway for long intestino-intestinal inhibitory reflexes. Gastroenterology. 1987; 92(3):594-603. DOI: 10.1016/0016-5085(87)90006-0. View

Sha S, Matsushima Y, Habu S, Mishima Y, Okamoto E . Extrinsic nervous control of retrograde giant contraction during vomiting in conscious dogs. Dig Dis Sci. 1996; 41(8):1546-50. DOI: 10.1007/BF02087898. View

Lang I, Sarna S, Shaker R . Gastrointestinal motor and myoelectric correlates of motion sickness. Am J Physiol. 1999; 277(3):G642-52. DOI: 10.1152/ajpgi.1999.277.3.G642. View

Ehrlein H . Retroperistaltism and duodenogastric reflux in dogs. Scand J Gastroenterol Suppl. 1981; 67:29-32. View

Christensen J, Stiles M, Rick G, Sutherland J . Comparative anatomy of the myenteric plexus of the distal colon in eight mammals. Gastroenterology. 1984; 86(4):706-13. View

BORISON H, Wang S . Functional localization of central coordinating mechanism for emesis in cat. J Neurophysiol. 1949; 12(5):305-13. DOI: 10.1152/jn.1949.12.5.305. View

Lang I, Marvig J, Sarna S, Condon R . Gastrointestinal myoelectric correlates of vomiting in the dog. Am J Physiol. 1986; 251(6 Pt 1):G830-8. DOI: 10.1152/ajpgi.1986.251.6.G830. View

10.

Blair P, Rhee P, Sanders K, Ward S . The significance of interstitial cells in neurogastroenterology. J Neurogastroenterol Motil. 2014; 20(3):294-317. PMC: 4102150. DOI: 10.5056/jnm14060. View

11.

Lang I, Marvig J, Sarna S . Comparison of gastrointestinal responses to CCK-8 and associated with vomiting. Am J Physiol. 1988; 254(2 Pt 1):G254-63. DOI: 10.1152/ajpgi.1988.254.2.G254. View

12.

Lang I, Marvig J . Functional localization of specific receptors mediating gastrointestinal motor correlates of vomiting. Am J Physiol. 1989; 256(1 Pt 1):G92-9. DOI: 10.1152/ajpgi.1989.256.1.G92. View

13.

Furness J . Types of neurons in the enteric nervous system. J Auton Nerv Syst. 2000; 81(1-3):87-96. DOI: 10.1016/s0165-1838(00)00127-2. View

14.

MacGilchrist A, Christensen J, Rick G . The distribution of myelinated nerve fibers in the mature opossum esophagus. J Auton Nerv Syst. 1991; 35(3):227-35. DOI: 10.1016/0165-1838(91)90101-8. View

15.

Lang I, Sarna S, Condon R . Gastrointestinal motor correlates of vomiting in the dog: quantification and characterization as an independent phenomenon. Gastroenterology. 1986; 90(1):40-7. DOI: 10.1016/0016-5085(86)90072-7. View

16.

GREGORY R . Changes in intestinal tone and motility associated with nausea and vomiting. J Physiol. 1946; 105(1):58-65. PMC: 1393581. View

17.

Christensen J . Regional variations in the gross structure of the enteric nervous system: some new views. Trans Am Clin Climatol Assoc. 1989; 101:21-36; discussion 36-7. PMC: 2376492. View

18.

Christensen J, Rick G . Shunt fascicles in the gastric myenteric plexus in five species. Gastroenterology. 1985; 88(4):1020-5. DOI: 10.1016/s0016-5085(85)80023-8. View

19.

BORISON H . Area postrema: chemoreceptor circumventricular organ of the medulla oblongata. Prog Neurobiol. 1989; 32(5):351-90. DOI: 10.1016/0301-0082(89)90028-2. View

20.

Brookes S . Classes of enteric nerve cells in the guinea-pig small intestine. Anat Rec. 2001; 262(1):58-70. DOI: 10.1002/1097-0185(20010101)262:1<58::AID-AR1011>3.0.CO;2-V. View