A Multi-centre Double-blind Controlled Trial of Glucagon and Insulin Therapy for Severe Acute Hepatitis

Overview

Journal Gastroenterol Jpn

Specialty Gastroenterology

Date 1989 Jun 1

PMID 2663609

Citations 2

Authors

H Oka

K Fujiwara

K Okita

H Ishii

A Sakuma

Affiliations

Soon will be listed here.

Abstract

A cooperative study was conducted to determine the efficacy of one week of treatment with infusion of 1 mg glucagon and 10 units insulin twice daily in severe acute hepatitis. Ninty-eight patients with either prothrombin time less than 60% or thrombotest or hepaplastin test less than 50% of normal were randomly assigned to hormone or placebo treatment. SGOT and SGPT values dropped after treatment with a gradual decrease or increase in total serum bilirubin or cholesterol levels similarly in both groups receiving hormone or placebo. Deranged prothrombin time improved more rapidly in the hormone group than in the placebo group. Glucagon and insulin infusion may stimulate recovery of the liver from injury.

Citing Articles

Insulin and glucagon therapy of acute hepatic failure.

Fujiwara K, Ogata I, Sato Y, Tomiya T, Ohta Y, Oka Y Dig Dis Sci. 1991; 36(6):809-15.

PMID: 2032521 DOI: 10.1007/BF01311241.

Treatment of fulminant hepatic failure with insulin and glucagon. A randomized, controlled trial.

Woolf G, Redeker A Dig Dis Sci. 1991; 36(1):92-6.

PMID: 1702048 DOI: 10.1007/BF01300094.

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