Lipid Fingerprinting in Mild Versus Severe Forms of Gestational Diabetes Mellitus

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Dec 4

PMID 26633694

Citations 7

Authors

Barbara Yasmin Gueuvoghlanian-Silva

Fernanda Bertuccez Cordeiro

Thalita Frutuoso Lobo

Thais Regiani Cataldi

Edson Guimaraes Lo Turco

Ricardo Pimenta Bertolla

Rosiane Mattar

Maria Regina Torloni

Silvia Daher

Affiliations

Soon will be listed here.

Abstract

The blood serum lipid profile of women with Gestational Diabetes Mellitus (GDM) is still under study. There are no data on the serum lipid profile of GDM patients with more severe (insulin treated) compared to milder forms (diet treated) GDM. The aim of our study was to analyze the blood serum lipid profile of patients with milder versus more severe forms of GDM and to compare these findings with those of healthy pregnant women. This cross-sectional analytical study included 30 insulin-treated GDM, 30 diet-only GDM and 30 healthy pregnant women. Serum lipid was extracted from the 90 participants and their lipid profiles were analyzed by lipid fingerprinting using liquid-chromatography-mass spectrometry. A total of 143 parent ions were differentially represented in each of the three groups, belonging to the following classes: Glycerophospholipids, Sterol Lipids, Sphingolipids, Prenol Lipids, Fatty Acyls and Glycerolipids. There were significant differences in the lipid profiles of healthy pregnant women compared to GDM patients and also between milder versus more severe forms of GDM. There are marked differences in lipid fingerprinting between healthy pregnant women compared to those with GDM in the third trimester. Moreover, the lipid profile of women with more severe forms of GDM differs considerably from that of women with milder forms of GDM. These findings may be useful to help clarify the pathogenesis of milder and more severe forms of GDM.

Citing Articles

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References

Lee A, Hiscock R, Wein P, Walker S, Permezel M . Gestational diabetes mellitus: clinical predictors and long-term risk of developing type 2 diabetes: a retrospective cohort study using survival analysis. Diabetes Care. 2007; 30(4):878-83. DOI: 10.2337/dc06-1816. View

Durn J, Marshall K, Farrar D, ODonovan P, Scally A, Woodward D . Lipidomic analysis reveals prostanoid profiles in human term pregnant myometrium. Prostaglandins Leukot Essent Fatty Acids. 2009; 82(1):21-6. DOI: 10.1016/j.plefa.2009.11.002. View

De Oliveira L, Camara N, Bonetti T, Lo Turco E, Bertolla R, Moron A . Lipid fingerprinting in women with early-onset preeclampsia: a first look. Clin Biochem. 2012; 45(10-11):852-5. DOI: 10.1016/j.clinbiochem.2012.04.012. View

Sharman M, Gomez A, Kraemer W, Volek J . Very low-carbohydrate and low-fat diets affect fasting lipids and postprandial lipemia differently in overweight men. J Nutr. 2004; 134(4):880-5. DOI: 10.1093/jn/134.4.880. View

Landon M, Spong C, Thom E, Carpenter M, Ramin S, Casey B . A multicenter, randomized trial of treatment for mild gestational diabetes. N Engl J Med. 2009; 361(14):1339-48. PMC: 2804874. DOI: 10.1056/NEJMoa0902430. View

Kullenberg D, Taylor L, Schneider M, Massing U . Health effects of dietary phospholipids. Lipids Health Dis. 2012; 11:3. PMC: 3316137. DOI: 10.1186/1476-511X-11-3. View

Kaur P, Rizk N, Ibrahim S, Luo Y, Younes N, Perry B . Quantitative metabolomic and lipidomic profiling reveals aberrant amino acid metabolism in type 2 diabetes. Mol Biosyst. 2012; 9(2):307-17. DOI: 10.1039/c2mb25384d. View

Riemens S, van Tol A, Scheek L, Dullaart R . Plasma cholesteryl ester transfer and hepatic lipase activity are related to high-density lipoprotein cholesterol in association with insulin resistance in type 2 diabetic and non-diabetic subjects. Scand J Clin Lab Invest. 2001; 61(1):1-9. DOI: 10.1080/00365510151067866. View

Hla T, Dannenberg A . Sphingolipid signaling in metabolic disorders. Cell Metab. 2012; 16(4):420-34. PMC: 3466368. DOI: 10.1016/j.cmet.2012.06.017. View

10.

Herrera E, Ortega-Senovilla H . Disturbances in lipid metabolism in diabetic pregnancy - Are these the cause of the problem?. Best Pract Res Clin Endocrinol Metab. 2010; 24(4):515-25. DOI: 10.1016/j.beem.2010.05.006. View

11.

Pertot T, Molyneaux L, Tan K, Ross G, Yue D, Wong J . Can common clinical parameters be used to identify patients who will need insulin treatment in gestational diabetes mellitus?. Diabetes Care. 2011; 34(10):2214-6. PMC: 3177752. DOI: 10.2337/dc11-0499. View

12.

Saisho Y, Miyakoshi K, Tanaka M, Shimada A, Ikenoue S, Kadohira I . Beta cell dysfunction and its clinical significance in gestational diabetes. Endocr J. 2010; 57(11):973-80. DOI: 10.1507/endocrj.k10e-231. View

13.

Bakiner O, Bozkirli E, Ozsahin K, Sariturk C, Ertorer E . Risk Factors That can Predict Antenatal Insulin Need in Gestational Diabetes. J Clin Med Res. 2013; 5(5):381-8. PMC: 3748663. DOI: 10.4021/jocmr1515w. View

14.

Ben-Haroush A, Yogev Y, Hod M . Epidemiology of gestational diabetes mellitus and its association with Type 2 diabetes. Diabet Med. 2004; 21(2):103-13. DOI: 10.1046/j.1464-5491.2003.00985.x. View

15.

Coen P, Goodpaster B . Role of intramyocelluar lipids in human health. Trends Endocrinol Metab. 2012; 23(8):391-8. PMC: 4908975. DOI: 10.1016/j.tem.2012.05.009. View

16.

Summers S . Sphingolipids and insulin resistance: the five Ws. Curr Opin Lipidol. 2010; 21(2):128-35. DOI: 10.1097/MOL.0b013e3283373b66. View

17.

Coleman R, Lee D . Enzymes of triacylglycerol synthesis and their regulation. Prog Lipid Res. 2003; 43(2):134-76. DOI: 10.1016/s0163-7827(03)00051-1. View

18.

. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2011; 34 Suppl 1:S62-9. PMC: 3006051. DOI: 10.2337/dc11-S062. View

19.

Volek J, Sharman M, Gomez A, DiPasquale C, Roti M, Pumerantz A . Comparison of a very low-carbohydrate and low-fat diet on fasting lipids, LDL subclasses, insulin resistance, and postprandial lipemic responses in overweight women. J Am Coll Nutr. 2004; 23(2):177-84. DOI: 10.1080/07315724.2004.10719359. View

20.

Karkkainen H, Laitinen T, Heiskanen N, Saarelainen H, Valtonen P, Lyyra-Laitinen T . Need for insulin to control gestational diabetes is reflected in the ambulatory arterial stiffness index. BMC Pregnancy Childbirth. 2013; 13:9. PMC: 3556301. DOI: 10.1186/1471-2393-13-9. View