A Panel of Four Decreased Serum MicroRNAs As a Novel Biomarker for Early Parkinson's Disease

Overview

Journal Biomarkers

Specialty Biochemistry

Date 2015 Dec 4

PMID 26631297

Citations 53

Authors

Hui Dong

Cheng Wang

Sunbin Lu

CuiYu Yu

Lei Huang

Wuruo Feng

Hui Xu

Xi Chen

Ke Zen

Qiao Yan

Weiguo Liu

Chunni Zhang

Chen-Yu Zhang

Affiliations

Soon will be listed here.

Abstract

Context: Sensitive, non-invasive biomarkers that facilitate Parkinson's disease (PD) detection and stage assignment are currently unavailable.

Objective: The objective of this study is to investigate the potential of circulating microRNAs (miRNAs) as novel biomarkers for PD.

Materials And Methods: Solexa sequencing technology and quantitative real-time PCR were applied to screen and verify altered serum miRNAs in PD patients.

Results: Serum miR-141, miR-214, miR-146b-5p, and miR-193a-3p were decreased significantly in PD patients compared with controls. Furthermore, the 4-miRNA panel enabled the differentiation of HY stage 1 and 2 PD patients from controls.

Discussion And Conclusion: The four serum miRNAs may represent novel biomarkers for the early detection of PD.

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