Detection of Occult Paroxysmal Atrial Fibrilation by Implantable Long-term Electrocardiographic Monitoring in Cryptogenic Stroke and Transient Ischemic Attack Population: a Study Protocol for Prospective Matched Cohort Study

Overview

Journal BMC Cardiovasc Disord

Publisher Biomed Central

Specialty Cardiology & Vascular Diseases

Date 2015 Dec 4

PMID 26631084

Citations 2

Authors

Andrea Petrovicova

Egon Kurca

Miroslav Brozman

Jozef Hasilla

Pavel Vahala

Peter Blasko

Andrea Andrasova

Robert Hatala

Lubos Urban

Stefan Sivak

Affiliations

Soon will be listed here.

Abstract

Background: Cardio-embolic etiology is the most frequently predicted cause of cryptogenic stroke/TIA. Detection of occult paroxysmal atrial fibrillation is crucial for selection of appropriate medication.

Methods: Enrolment of eligible cryptogenic stroke and TIA patients began in 2014 and will continue until 2018. The patients undergo long-term (12 months) ECG monitoring (implantable loop recorder) and testing for PITX2 (chromosome 4q25) and ZFHX3 (chromosome 16q22) gene mutations. There will be an appropriate control group of age- and sex-matched healthy volunteers. To analyse the results descriptive statistics, statistical tests for group differences, and correlation analyses will be used.

Discussion: In our study we are focusing on a possible correlation between detection of atrial fibrillation by an implantable ECG recorder, and PITX2 and/or ZFHX3 gene mutations in cryptogenic stroke/TIA patients. A correlation could lead to implementation of this genomic approach to cryptogenic stroke/TIA diagnostics and management. The results will be published in 2018.

Trial Registration: ClinicalTrials.gov: NCT02216370 .

Citing Articles

Epicardial Fat Thickness and Free Fatty Acid Level are Predictors of Acute Ischemic Stroke with Atrial Fibrillation.

Cho K, Kim B, Cho S, Lee J, Kim M, Yoo B J Cardiovasc Imaging. 2018; 26(2):65-74.

PMID: 29971268 PMC: 6024837. DOI: 10.4250/jcvi.2018.26.e1.

The complexity of atrial fibrillation newly diagnosed after ischemic stroke and transient ischemic attack: advances and uncertainties.

Cerasuolo J, Cipriano L, Sposato L Curr Opin Neurol. 2016; 30(1):28-37.

PMID: 27984303 PMC: 5321114. DOI: 10.1097/WCO.0000000000000410.

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