Mast Cells Participate in Corneal Development in Mice

Overview

Journal Sci Rep

Specialty Science

Date 2015 Dec 3

PMID 26627131

Citations 27

Authors

Jun Liu

Ting Fu

Fang Song

Yunxia Xue

Chaoyong Xia

Peng Liu

Hanqing Wang

Jiajun Zhong

Quanrong Li

Jiansu Chen

Yangqiu Li

Dongqing Cai

Zhijie Li

Affiliations

Soon will be listed here.

Abstract

The development of the cornea, a highly specialized transparent tissue located at the anterior of the eye, is coordinated by a variety of molecules and cells. Here, we report that mast cells (MCs), recently found to be involved in morphogenesis, played a potentially important role in corneal development in mice. We show that two different waves of MC migration occurred during corneal development. In the first wave, MCs migrated to the corneal stroma and became distributed throughout the cornea. This wave occurred by embryonic day 12.5, with MCs disappearing from the cornea at the time of eyelid opening. In the second wave, MCs migrated to the corneal limbus and became distributed around limbal blood vessels. The number of MCs in this region gradually increased after birth and peaked at the time of eyelid opening in mice, remaining stable after postnatal day 21. We also show that integrin α4β7 and CXCR2 were important for the migration of MC precursors to the corneal limbus and that c-Kit-dependent MCs appeared to be involved in the formation of limbal blood vessels and corneal nerve fibers. These data clearly revealed that MCs participate in the development of the murine cornea.

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