Extract Inhibits Diethylnitrosamine-induced Hepatocarcinogenesis in Rats

Overview

Journal Oncol Lett

Specialty Oncology

Date 2015 Dec 2

PMID 26622559

Citations 8

Authors

Walied Abdo

Akihiro Hirata

Mostafa Shukry

Tarek Kamal

Essam Abdel-Sattar

Engi Mahrous

Tokuma Yanai

Affiliations

Soon will be listed here.

Abstract

is an Egyptian desert plant that contains polyphenol antioxidants. The present study examined the chemopreventive effect of an extract of in a rat model of hepatocarcinogenesis. Male Wistar rats (n=40) were administered 100 mg/kg diethylnitrosamine (DEN) by intraperitoneal (i.p.) injection once a week for 3 weeks. Subsequently, depending on whether the rats received further administration of 0.8 mg/kg carbon tetrachloride (CCl) i.p. once a week for 7 weeks and 100 mg/kg extract in their diet for 7 weeks, the rats were divided into four groups as follows: Group 1, treatment with DEN alone; group 2, treatment with DEN and extract; group 3, treatment with DEN and CCl; and group 4, treatment with DEN, CCl and extract. The supplementation of extract significantly suppressed the elevation in serum liver enzyme levels, including aspartate aminotransferase, alanine transaminase and γ-glutamyl transferase, and reduced the degree of oval cell proliferation induced by DEN and CCl. In addition, extract significantly decreased the number and area of glutathione S-transferase placental form-positive preneoplastic hepatic foci induced by DEN, with or without CCl treatment. To the best of our knowledge, the present study is the first to provide definitive evidence of the hepatoprotective and chemopreventive effects of .

Citing Articles

The Therapeutic Effect of Myrrh (Commiphora molmol) and Doxorubicin on Diethylnitrosamine Induced Hepatocarcinogenesis in Male Albino Rats.

Anwar H, Moghazy A, Osman A, Abdel Rahman A Asian Pac J Cancer Prev. 2021; 22(7):2153-2163.

PMID: 34319038 PMC: 8607089. DOI: 10.31557/APJCP.2021.22.7.2153.

Ameliorative Effects of against the Initiation of Hepatocarcinogenesis Induced by Diethylnitrosamine in a Rat Model: Regulation of and Gene Expression.

Assar D, Mokhbatly A, Ghazy E, Ragab A, Abou Asa S, Abdo W Antioxidants (Basel). 2021; 10(6).

PMID: 34200190 PMC: 8228954. DOI: 10.3390/antiox10060922.

Anti-Proliferative and Pro-Apoptotic Effects of (L'Her.) Methanolic Extract in Human Triple-Negative MDA-MB-231 Breast Cancer Cells.

Alehaideb Z, Alghamdi S, Yahya W, Al-Eidi H, Alharbi M, Alaujan M J Evid Based Integr Med. 2020; 25:2515690X20978391.

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The Effects of Extract and Low-Intensity Ultrasound on Motility, Viability, and DNA Fragmentation of Human Frozen-Thawed Semen Samples.

Ekrami H, Movahedin M, Koosha F, Mazaheri Z, Mokhtari-Dizaji M Int J Fertil Steril. 2020; 14(2):84-90.

PMID: 32681619 PMC: 7382682. DOI: 10.22074/ijfs.2020.5896.

Fatty changes associated with N-Nitrosodiethylamine (DEN) induced hepatocellular carcinoma: a role of sonic hedgehog signaling pathway.

Tripathy A, Thakurela S, Sahu M, Uthansingh K, Singh A, Narayan J Genes Cancer. 2020; 11(1-2):66-82.

PMID: 32577158 PMC: 7289904. DOI: 10.18632/genesandcancer.203.

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