Ambulatory Blood Pressure and Tubulointerstitial Injury in Patients with IgA Nephropathy

Overview

Journal Clin Kidney J

Publisher Oxford University Press

Specialty Nephrology

Date 2015 Nov 28

PMID 26613030

Citations 4

Authors

Kotaro Haruhara

Nobuo Tsuboi

Kentaro Koike

Go Kanzaki

Yusuke Okabayashi

Yoichi Miyazaki

Tetsuya Kawamura

Makoto Ogura

Takashi Yokoo

Affiliations

Soon will be listed here.

Abstract

Background: Few studies have been conducted to assess the ambulatory blood pressure (ABP) in IgA nephropathy (IgAN) patients. This study aimed to determine the relationships between ABP and renal histopathological findings assessed using the Oxford classification (OC) and the Japanese classification (JC), which have recently established histopathological criteria for IgAN.

Methods: This cross-sectional study included biopsy-diagnosed IgAN patients, in whom both a renal biopsy and ABP measurement were performed. The histopathological findings were assessed using the OC and the JC and were analyzed in relation to the ABP.

Results: A total of 111 IgAN patients were included. The score of interstitial fibrosis and tubular atrophy (T score) using the OC was a significantly associated factor with both the daytime and nighttime ABP values. In contrast, the other histopathological scores, including mesangial hypercellularity, endocapillary hypercellularity and segmental glomerulosclerosis, did not show significant associations with the ABP. The histological grade (H-grade) using the JC, which was based on the sum of injured glomeruli, was associated with the daytime ABP, but not with the nighttime ABP. The associations between the T score using the OC (%) and the daytime and nighttime ABP values were independent of age, gender, renal function, proteinuria and the use of antihypertensive medications, whereas the H-grade using the JC (%) did not show significant associations after adjusting for these clinical parameters.

Conclusions: These results suggest that the T score using the OC is the most relevant renal histopathological parameter associated with abnormalities of circadian blood pressure in IgAN patients.

Citing Articles

Sodium excretion per nephron and nighttime hypertension in patients with IgA nephropathy.

Marumoto H, Tsuboi N, Sasaki T, Okabayashi Y, Haruhara K, Kanzaki G Hypertens Res. 2024; 47(9):2616-2618.

PMID: 39014116 DOI: 10.1038/s41440-024-01800-w.

Non-dipping pulse rate and chronic changes of the kidney in patients with chronic kidney disease.

Oba R, Kanzaki G, Haruhara K, Sasaki T, Okabayashi Y, Koike K Front Cardiovasc Med. 2023; 10:911773.

PMID: 36891248 PMC: 9986326. DOI: 10.3389/fcvm.2023.911773.

Prognostic significance of the extent of tubulointerstitial lesions in patients with IgA nephropathy.

Tang X, Wen Q, Zhou Q, Yang Q, Chen W, Yu X Int Urol Nephrol. 2022; 55(3):671-677.

PMID: 36050583 DOI: 10.1007/s11255-022-03286-2.

High Blood Pressure Is Associated with Tubulointerstitial Damage along with Glomerular Damage in Glomerulonephritis. A large Cohort Study.

Bazzi C, Seccia T, Napodano P, Campi C, Caroccia B, Cattarin L J Clin Med. 2020; 9(6).

PMID: 32492793 PMC: 7355847. DOI: 10.3390/jcm9061656.

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