Assessment of Dioxin-like Activity in PM Air Samples from an Industrial Location in Algeria, Using the DRE-CALUX Bioassay

Overview

Journal Environ Sci Pollut Res Int

Publisher Springer

Specialties Environmental Health
Toxicology

Date 2015 Nov 28

PMID 26611627

Citations 1

Authors

Sidali Khedidji

Kim Croes

Noureddine Yassaa

Riad Ladji

Michael S Denison

Willy Baeyens

Marc Elskens

Affiliations

Soon will be listed here.

Abstract

When compared to the European guidelines, PM (particulate matter up to 10-μm size) concentrations in Algeria are often exceeding the maximum limits, and in general, no information exists on the compounds bound on its surface. The objective of this study was to measure the dioxin-like activity of polychlorinated dibenzodioxines and dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (PCBs) in the PM fraction at the Sour El Ghozlane cement plant in Algeria. PM samples (n = 23) were taken between 24 March and 15 April 2013, using a medium volume sampler and 47-mm PTFE filters. The 24-h samples were dried to determine the PM content and afterward extracted, cleaned up, and analyzed with the dioxin-responsive element-chemical-activated luciferase gene expression (DRE-CALUX) bioassay. Our results showed that the measured bioanalytical equivalents (BEQs) were similar to those in other international industrial sites worldwide. The PCDD/Fs and dioxin-like PCBs (dl-PCBs) were positively correlated (rho = 0.6, p = 0.002), indicating that they have similar sources. Furthermore, samples from March showed higher PCDD/F and dl-PCB BEQs and humidity but lower temperatures compared to samples from April, while there was no difference in the PM concentrations between the two months. These results reveal that PM alone is not a good proxy and that meteorological conditions are an important factor in assessing dioxin-like pollution in the atmosphere. It seems that, at present, there is no health hazard through direct airborne human exposure to dioxin-like pollutants in PM from this site. However, it is important to monitor these POPs for a longer period of time and also to gain more insight in their distribution between the particulate and gas phase in relation to meteorological conditions.

Citing Articles

Monitoring polychlorinated dibenzo-p-dioxins/dibenzofurans and dioxin-like polychlorinated biphenyls in Africa since the implementation of the Stockholm Convention-an overview.

Pius C, Sichilongo K, Koosaletse Mswela P, Dikinya O Environ Sci Pollut Res Int. 2018; 26(1):101-113.

PMID: 30414030 DOI: 10.1007/s11356-018-3629-z.

References

Katsouyanni K, Touloumi G, Samoli E, Gryparis A, Le Tertre A, Monopolis Y . Confounding and effect modification in the short-term effects of ambient particles on total mortality: results from 29 European cities within the APHEA2 project. Epidemiology. 2001; 12(5):521-31. DOI: 10.1097/00001648-200109000-00011. View

Elskens M, Baston D, Stumpf C, Haedrich J, Keupers I, Croes K . CALUX measurements: statistical inferences for the dose-response curve. Talanta. 2011; 85(4):1966-73. DOI: 10.1016/j.talanta.2011.07.014. View

Yubero E, Carratala A, Crespo J, Nicolas J, Santacatalina M, Nava S . PM₁₀ source apportionment in the surroundings of the San Vicente del Raspeig cement plant complex in southeastern Spain. Environ Sci Pollut Res Int. 2010; 18(1):64-74. DOI: 10.1007/s11356-010-0352-9. View

Dionisio K, Arku R, Hughes A, Vallarino J, Carmichael H, Spengler J . Air pollution in Accra neighborhoods: spatial, socioeconomic, and temporal patterns. Environ Sci Technol. 2010; 44(7):2270-6. DOI: 10.1021/es903276s. View

Davy C . Legislation with respect to dioxins in the workplace. Environ Int. 2004; 30(2):219-33. DOI: 10.1016/S0160-4120(03)00171-5. View

Yassaa N, Cecinato A . Composition of torched crude oil organic particulate emitted by refinery and its similarity to atmospheric aerosol in the surrounding area. Chemosphere. 2005; 60(11):1660-6. DOI: 10.1016/j.chemosphere.2005.02.041. View

Sanctorum H, Elskens M, Baeyens W . Bioassay (CALUX) measurements of 2,3,7,8-TCDD and PCB 126: interference effects. Talanta. 2008; 73(1):185-8. DOI: 10.1016/j.talanta.2007.03.009. View

Denison M, Heath-Pagliuso S . The Ah receptor: a regulator of the biochemical and toxicological actions of structurally diverse chemicals. Bull Environ Contam Toxicol. 1998; 61(5):557-68. DOI: 10.1007/pl00002973. View

Kiguchi O, Kobayashi T, Wada Y, Saitoh K, Ogawa N . Polychlorinated dibenzo-p-dioxins and dibenzofurans in paddy soils and river sediments in Akita, Japan. Chemosphere. 2006; 67(3):557-73. DOI: 10.1016/j.chemosphere.2006.09.044. View

10.

Castro-Jimenez J, Eisenreich S, Ghiani M, Mariani G, Skejo H, Umlauf G . Atmospheric occurrence and deposition of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in the open Mediterranean Sea. Environ Sci Technol. 2010; 44(14):5456-63. DOI: 10.1021/es100718n. View

11.

van den Berg M, Birnbaum L, Bosveld A, Brunstrom B, Cook P, Feeley M . Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ Health Perspect. 1998; 106(12):775-92. PMC: 1533232. DOI: 10.1289/ehp.98106775. View

12.

Cortes J, Gonzalez C, Morales L, Abalos M, Abad E, Aristizabal B . PCDD/PCDF and dl-PCB in the ambient air of a tropical Andean city: passive and active sampling measurements near industrial and vehicular pollution sources. Sci Total Environ. 2014; 491-492:67-74. DOI: 10.1016/j.scitotenv.2014.01.113. View

13.

Croes K, Van Langenhove K, Elskens M, Desmedt M, Roekens E, Kotz A . Analysis of PCDD/Fs and dioxin-like PCBs in atmospheric deposition samples from the Flemish measurement network: Optimization and validation of a new CALUX bioassay method. Chemosphere. 2010; 82(5):718-24. DOI: 10.1016/j.chemosphere.2010.10.092. View

14.

Machala M, Ciganek M, Blaha L, Minksova K, Vondrack J . Aryl hydrocarbon receptor-mediated and estrogenic activities of oxygenated polycyclic aromatic hydrocarbons and azaarenes originally identified in extracts of river sediments. Environ Toxicol Chem. 2002; 20(12):2736-43. View

15.

Pedersen M, Halldorsson T, Mathiesen L, Mose T, Brouwer A, Hedegaard M . Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother-newborn pairs. Environ Int. 2010; 36(4):344-351. DOI: 10.1016/j.envint.2010.02.002. View

16.

Samet J, Zeger S, Dominici F, Curriero F, Coursac I, Dockery D . The National Morbidity, Mortality, and Air Pollution Study. Part II: Morbidity and mortality from air pollution in the United States. Res Rep Health Eff Inst. 2001; 94(Pt 2):5-70; discussion 71-9. View

17.

Mkoma S, Chi X, Maenhaut W . Characteristics of carbonaceous aerosols in ambient PM10 and PM2.5 particles in Dar es Salaam, Tanzania. Sci Total Environ. 2009; 408(6):1308-14. DOI: 10.1016/j.scitotenv.2009.10.054. View

18.

Mocarelli P, Gerthoux P, Needham L, Patterson Jr D, Limonta G, Falbo R . Perinatal exposure to low doses of dioxin can permanently impair human semen quality. Environ Health Perspect. 2011; 119(5):713-8. PMC: 3094426. DOI: 10.1289/ehp.1002134. View

19.

Croes K, Vandermarken T, Van Langenhove K, Elskens M, Desmedt M, Roekens E . Analysis of PCDD/Fs and dioxin-like PCBs in atmospheric deposition samples from the Flemish measurement network: correlation between the CALUX bioassay and GC-HRMS. Chemosphere. 2012; 88(7):881-7. DOI: 10.1016/j.chemosphere.2012.03.097. View

20.

Croes K, Colles A, Koppen G, De Galan S, Vandermarken T, Govarts E . Determination of PCDD/Fs, PBDD/Fs and dioxin-like PCBs in human milk from mothers residing in the rural areas in Flanders, using the CALUX bioassay and GC-HRMS. Talanta. 2013; 113:99-105. PMC: 3690775. DOI: 10.1016/j.talanta.2013.03.086. View